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Last Updated: April 19, 2024

Claims for Patent: 4,568,666

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Summary for Patent: 4,568,666

Title:	Carboxylalkyl peptide derivatives
Abstract:	This invention encompasses novel carboxyalkyl peptide derivatives which are collagenase inhibitors.
Inventor(s):	McCullagh; Keith G. (Princes Risborough, GB), Wadsworth; Harry J. (High Wycombe, GB), Hann; Michael M. (Watlington, GB)
Assignee:	G. D. Searle & Co. (Skokie, IL)
Application Number:	06/662,129
Patent Claims:	1. A compound of the formula: ##STR31## and the pharmaceutically acceptable acid addition salts thereof wherein R'.sub.2 represents hydroxy, alkoxy, cycloalkoxy, aralkoxy or substituted alkoxy wherein the substituent is selected from alkylaminocarbonyl or the group ##STR32## R'.sub.3 represents alkylamino or aralkylamino; and the stereochemistry of the carbon atom marked by the asterisk is R or S or a diastereomeric mixture thereof. 2. A compound according to claim 1 wherein R'.sub.2 is straight or branched chain alkoxy of from about 1 to 6 carbon atoms. 3. A compound according to claim 2 wherein R'.sub.2 is selected from n-propoxy or n-pentoxy. 4. A compound according to claim 1 wherein R'.sub.3 is alkylamino. 5. A compound according to claim 4 wherein said alkylamino is methylamino. 6. A compound according to claim 1 wherein the stereochemistry of the carbon atom marked by the asterisk is R. 7. A compound according to claim 1 of the formula. ##STR33## or a pharmaceutically acceptable acid addition salt thereof. 8. A compound according to claim 1 of the formula ##STR34## or a pharmaceutically acceptable acid addition salt thereof. 9. A method of promoting an antiarthritic effect in a mammal in need thereof comprising administering thereto a collagenase inhibiting effective amount of a compound according to claim 1. 10. A method according to claim 9 wherein said compound is of the formula: ##STR35##

Details for Patent 4,568,666

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2004-04-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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