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Last Updated: March 28, 2024

Claims for Patent: 4,416,874


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Summary for Patent: 4,416,874
Title: Injectable compositions of BBM-928A
Abstract:BBM-928A solutions suitable for parenteral use in animal experiments and having concentrations in the range of 1 mg/ml to 5 mg/ml are described.
Inventor(s): Kaplan; Murray A. (Syracuse, NY), Shinal; Edward C. (Manlius, NY)
Assignee: Bristol-Myers Company (New York, NY)
Application Number:06/354,998
Patent Claims:1. A pharmaceutical composition suitable for intravenous injection comprising a sterile aqueous solution containing from 1 mg. to 5 mg. of BBM 928A per milliliter, and sufficient of a pharmaceutically acceptable water soluble base to solubilize said BBM 928A and confer a pH value of from pH 11.0 to 11.5 upon said solution wherein said base is selected from the group consisting of sodium hydroxide, trisodium phosphate, sodium carbonate, pyrrolidine, triethylamine, piperidine, glucosamine, N-methylglucamine, and the sodium salt of an organic acid selected from the group consisting of glycine, aspartic acid, cysteine, phthalic acid, succinic acid, and tyrosine.

2. The intravenous solution of claim 1 wherein said base is sodium hydroxide.

3. The intravenous solution of claim 1 wherein said base is trisodium orthophosphate.

4. The intravenous solution of claim 1 wherein said base is the sodium salt of glycine, aspartic acid, cysteine, phthalic acid, succinic acid, or tyrosine.

5. The intravenous solution of claim 1 wherein said base is pyrrolidine, triethylamine, or piperidine.

6. A dry composition suitable for constitution with sterile water for injection comprising one part by weight of BBM 928A and 0.65 parts by weight of trisodium orthophosphate.

7. The composition of claim 6 in dosage unit form providing 10 mg. of BBM 928A for constitution with 2 milliliters of water.

8. A pharmaceutical composition suitable for intravenous injection comprising a sterile aqueous solution containing one part by weight of BBM 928A and 0.65 parts by weight of trisodium orthophosphate and sufficient water to provide a BBM 928A concentration of from 1 to 5 mg. per milliliter.

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