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Last Updated: April 25, 2024

Claims for Patent: 4,361,574

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Summary for Patent: 4,361,574

Title:	Inhibitors of mammalian collagenase
Abstract:	A method of inhibiting mammalian collagenase by using 3-(p-substituted phenyl)-thiazolo[3,2-a]benzimidazole-2-alkanoic acids and esters thereof, and the pharmaceutically acceptable salts thereof.
Inventor(s):	Grant; Norman H. (Wynnewood, PA), Clark; Donald E. (Norristown, PA)
Assignee:	American Home Products Corporation (New York, NY)
Application Number:	06/307,710
Patent Claims:	1. A method of inhibiting mammalian collagenase in mammals afflicted with a disease state in which collagen is broken down by collagenase, which comprises administering to such an afflicted mammal an amount sufficient to reverse said collagenase-induced collagen break down of a collagenase inhibitor having the formula: ##STR3## wherein R is hydrogen or lower alkyl and R.sub.1 is lower alkyl, lower alkoxy, trifluoromethyl or halo, n is 1 or 2 and pharmaceutically acceptable salts thereof. 2. The method of claim 1 wherein R is hydrogen, R.sub.1 is chloro and n is 1. 3. The method of claim 1, wherein R is hydrogen, R.sub.1 is fluoro and n is 1. 4. The method of claim 1, wherein R is hydrogen, R.sub.1 is bromo and n is 1. 5. The method of claim 1, wherein R is hydrogen, R.sub.1 is methyl and n is 1. 6. The method of claim 1, wherein R is hydrogen, R.sub.1 is methoxy and n is 1. 7. The method of claim 1, wherein R is hydrogen, R.sub.1 is trifluoromethyl and n is 1.

Details for Patent 4,361,574

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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