Claims for Patent: 4,350,698

Summary for Patent: 4,350,698

Title:	Antiallergic imidosulfamides
Abstract:	Imidosulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and chlorosulfonylisocyanate in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
Inventor(s):	Gleason; John G. (Delran, NJ), Hill; David T. (North Wales, PA)
Assignee:	SmithKline Corporation (Philadelphia, PA)
Application Number:	06/305,433
Patent Claims:	1. A compound of the formula (I) ##STR5## wherein X is hydrogen, bromo, chloro, or methyl; and Y is bromo, chloro, methyl or 7-benzeneaminosulfonyl radical of the formula ##STR6## in which R.sub.1 is hydrogen, bromo, chloro or methyl and R.sub.2 is bromo or chloro; or an alkali metal salt of said compound. 2. A compound according to claim 1 wherein X is hydrogen, bromo, chloro or methyl and Y is bromo, chloro or methyl. 3. A compound according to claim 2 wherein X is hydrogen and Y is 5-bromo or 6-chloro. 4. A compound according to claim 2 wherein X is 7-chloro and Y is 6-chloro or 8-chloro. 5. A compound according to claim 2 which is N-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-2yl)-carbonyl-7,8-dichloro-1 ,2,3,4-tetrahydrosioquinoline-2-sulfonamide or an alkali metal salt of said compound. 6. A compound according to claim 2 wherein X is 7-methyl and Y is 8-chloro. 7. A compound according to claim 1 wherein X is hydrogen and Y is a 7-benzeneaminosulfonyl radical of the formula ##STR7## which R.sub.1 is hydrogen, bromo, chloro or methyl and R.sub.2 is bromo or chloro; or an alkali metal salt of said compound. 8. A compound according to claim 7 wherein R is hydrogen and R.sub.2 is 3-chloro or 3-bromo. 9. A pharmaceutical composition for inhibiting the symptoms of asthma comprising a pharmaceutical carrier or diluent and an amount sufficient to produce said inhibition of a compound of claim 1. 10. A pharmaceutical composition according to claim 9 in a form suitable for administration by inhalation. 11. A pharmaceutical composition according to claim 9 comprising a solution or suspension of the active ingredient in sterile water. 12. A pharmaceutical composition according to claim 9 in the form of an aerosol formulation. 13. A pharmaceutical composition according to claim 9 in which the pharmaceutical carrier or diluent is a solid.

Details for Patent 4,350,698

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23