Claims for Patent: 4,323,467

Summary for Patent: 4,323,467

Title:	Contact lens cleaning, storing and wetting solutions
Abstract:	A solution for cleaning, storing or wetting contact lenses which comprises a poly(oxyethylene)-poly(oxypropylene) substituted ethylenediamine surfactant having a molecular weight between 1,600 and 27,000; a germicidal agent; a viscosity builder; a tonicity agent; a sequestering agent and water.
Inventor(s):	Fu; Cherng-Chyi (Sunnyvale, CA)
Assignee:	Syntex (U.S.A.) Inc. (Palo Alto, CA)
Application Number:	06/209,795
Patent Claims:	1. A contact lens cleaning, storing or wetting solution which comprises: (a) a poly(oxyethylene)-poly(oxypropylene) substituted ethylene diamine nonionic surfactant which is present in an amount of 0.01% to 40% by weight/volume (w/v); (b) at least one germicide which is present in an amount of 0.0005% to 0.05% (w/v); (c) a water soluble, cellulose-derived viscosity builder which is present in an amount of 0.01% to 5.0% (w/v); (d) at least one tonicity agent which is present in an amount of 0.4% to 1.7% (w/v); (e) a sequestering agent which is present in an amount of 0.01% to 1.0% (w/v); and (f) water. 2. The composition of claim 1 wherein: (a) said surfactant has a cloud point in excess of 50.degree. C. for a 10% solution; (b) said germicide is an organic mercurial compound or a quaternary amine compound; (c) said viscosity builder is hydroxymethylcellulose, hydroxyethyl cellulose, methylcellulose, hydroxypropyl methylcellulose or sodium carboxymethylcellulose; (d) said tonicity agent is an alkali metal halide; (e) said sequestering agent is ethylenediaminetetraacetic acid or the salts thereof; and (f) water. 3. The composition of claim 2, wherein: (a) said surfactant is present in an amount of 0.1% to 15%; (b) said germicide is present in an amount of 0.001% to 0.02%; (c) said viscosity builder is present in an amount of 0.1% to 1.0%; (d) said tonicity agent is present in an amount of 0.6% to 1.1%; (e) said sequestering agent is present in an amount of 0.05% to 0.5%; and (f) water in a quantity sufficient to bring total composition to unity. 4. The composition of claim 3, wherein: (a) said surfactant has a CTFA designation of 1304 and a molecular weight of 10500; (b) said germicide is thimerosal; (c) said viscosity builder is hydroxyethyl cellulose; (d) said tonicity agent is sodium chloride; (e) said sequestering agent is disodium ethylenediaminetetraacetic acid; and (f) deionized, sterilized water. 5. The composition of claim 4, wherein: (a) said surfactant is present in the amount of 1.5%; (b) said germicide is present in the amount of 0.004%; (c) said viscosity builder is present in the amount of 0.5%; (d) said tonicity agent is present in the amount of 0.8%; (e) said sequestering agent is present in the amount of 0.1%; and (f) water in a quantity sufficient to bring the total composition volume to unity. 6. The composition of claim 3, wherein: (a) said surfactant has a CTFA designation of 1104 and a molecular weight of 8300; (b) said germicide is thimerosal and benzalkonium chloride; (c) said viscosity builder is hydroxyethylcellulose; (d) said tonicity agent is sodium chloride; (e) said sequestering agent is disodium ethylenediaminetetraacetic acid; and (f) deionized, sterile water. 7. The composition of claim 6, wherein: (a) said surfactant is present in the amount of 0.5%; (b) said germicide thimerosal is present in the amount of 0.001% and benzalkonium chloride is present in the amount of 0.01%; (c) said viscosity builder is present in the amount of 0.5%; (d) said tonicity agent is present in the amount of 0.8%; (e) said sequestering agent is present in the amount of 0.1%; and (f) water in a quantity sufficient to bring the total composition to unity. 8. A process for cleaning, storing or wetting a contact lens which comprises contacting the surface of a lens with the composition of claim 1. 9. A process for preparing the composition of claim 1 which comprises: (a) mixing the tonicity agent with said viscosity builder; (b) stirring this mixture into hot water; (c) adding the remaining ingredients to this aqueous mixture; (d) sterilizing the solution; and (e) diluting to the desired final concentration by the addition of sterile water.

Details for Patent 4,323,467

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23