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Last Updated: April 23, 2024

Claims for Patent: 4,288,426

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Summary for Patent: 4,288,426

Title:	Serological test for syphilis
Abstract:	Serological method of testing for Treponema pallidum antibodies in human serum which is diluted with physiological saline to a dilution of from 1:20 to 1:100 by incubating the diluted serum with a lysate of T. pallidum adsorbed on an inert adsorbent and detecting an antigen-antibody conjugate when antibodies are present.
Inventor(s):	Stevens; Roy W. (Schenectedy, NY)
Assignee:	Research Corporation (New York, NY)
Application Number:	06/132,180
Patent Claims:	1. A serological method for determining the presence of Treponema pallidum antibodies in human serum which comprises diluting the serum to be tested in physiological saline solution to a dilution of from 1:20 to 1:100, and thereafter incubating the diluted serum with a lysate of Treponema pallidum adsorbed on an inert adsorbent to form an antigen-antibody conjugate when said antibodies are present, and detecting the presence of said conjugate. 2. A serological method as claimed in claim 1, wherein the presence of the conjugate is detected by reaction with an antibody to human immunoglobulins, said antibody labeled with a chemical which fluoresces when exposed to ultraviolet light. 3. A method as in claim 2, wherein the chemical label is selected from the group consisting of fluorescein, rhodamine and auramine. 4. A serological method as claimed in claim 1, wherein the presence of the conjugate is detected by reaction with an antibody to human immunoglobulins, said antibody labeled with an enzyme. 5. A method as in claim 4, wherein the enzyme is selected from the group consisting of peroxidase, B-glucuronidase, B-D-glucosidase, B-D-galactosidase, urease, glucose oxidase plus peroxidase, galactose oxidase plus peroxidase, alkaline phosphatase, and acid phosphatase. 6. A serological method as in claim 1, wherein the presence of the conjugate is detected by reaction with an antibody to human immunoglobulins labeled with a radioactive element. 7. A method as in claim 6, wherein the radioactive element label is selected from the group consisting of .sup.14 C, .sup.125 I, .sup.131 I, and .sup.35 S. 8. A method as in any of claims 2-7 wherein the animal antibody is directed specifically to human immunoglobulin G or to human immunoglobulin M.

Details for Patent 4,288,426

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Csl Behring Ag	CARIMUNE, CARIMUNE NF, PANGLOBULIN, SANDOGLOBULIN	immune globulin intravenous (human)	For Injection	102367	07/27/2000	⤷ Try a Trial	2040-01-28
Csl Behring Ag	PRIVIGEN	immune globulin intravenous (human), 10% liquid	Injection	125201	07/26/2007	⤷ Try a Trial	2040-01-28
Csl Behring Ag	PRIVIGEN	immune globulin intravenous (human), 10% liquid	Injection	125201	10/02/2009	⤷ Try a Trial	2040-01-28
Csl Behring Ag	PRIVIGEN	immune globulin intravenous (human), 10% liquid	Injection	125201	02/07/2013	⤷ Try a Trial	2040-01-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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