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Last Updated: March 29, 2024

Claims for Patent: 4,273,703


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Summary for Patent: 4,273,703
Title: Interferon product and process for its preparation
Abstract:Exogenic porcine interferon for administration in human beings. The porcine interferon shows antiviral protecting activity on cultured human cells and is substantially free of any immunoelectrophoresis bands which are not identical or partially identical with bands in human leucocyte interferon or human agammaserum. A process for preparing the porcine interferon by harvesting, isolating and, if desired, priming porcine leucocytes, treating them with an interferon inductor and incubating them and obtaining the interferon formed, the process being characterized in using, as added protein source in any of the said stages, a source which is substantially free of immunoelectrophoresis band which are not identical or partially identical with bands in human agammaserum.
Inventor(s): Osther; Kurt B. (Naerum, DK), Jensen; Werner K. (Roskilde, DK)
Assignee: Ess-Food Eksport-Svineslagteriernes Salgsforening (Copenhagen, DK)
Application Number:05/955,389
Patent Claims:1. A process for preparing exogenic porcine leucocyte interferon which shows antiviral protective activity in human cells comprising:

harvesting and isolating porcine leucocytes:

treating said porcine leucocytes with an interferon inductor;

incubating said treated porcine leucocytes;

adding a protein source which in immunoelectrophoreses is substantially composed of bands which are identical or partially identical with corresponding bands in human agammaserum when using, as precipitating antibody, antitotal human serum protein, antihuman IgG, antihuman IgA, antihuman IgM or antihuman albumin.

2. The process of claim 1, wherein the porcine leucocyte is primed.

3. A process according to claim 1 in which the protein source is selected from the group consisting of human agammaserum, human agammaplasma, human albumin, human hemoglobin from hemolyzed erythrocytes, porcine agammaserum, porcine agammaplasma, porcine albumin, and porcine hemoglobin from hemolyzed erythrocytes.

4. The process of claim 3, wherein the protein source is porcine agammaserum and agammaplasma.

Details for Patent 4,273,703

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 10/21/1942 ⤷  Try a Trial 1998-06-16
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 03/03/1954 ⤷  Try a Trial 1998-06-16
Csl Behring Ag ALBURX albumin (human) Injection 102366 07/23/1976 ⤷  Try a Trial 1998-06-16
Grifols Biologicals Llc ALBUTEIN albumin (human) Injection 102478 08/15/1978 ⤷  Try a Trial 1998-06-16
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 02/17/1995 ⤷  Try a Trial 1998-06-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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