You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 18, 2024

Claims for Patent: 4,263,293

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,263,293

Title:	Heterocyclic containing amides as inhibitors of mammalian collagenase
Abstract:	Mammalian collagenase is inhibited by compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl; R.sub.2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl; R.sub.3 is alkyl of 3 to 8 carbon atoms, cycloalkyl, aryl, or arylalkyl; and n is an integer of 1 to 20.
Inventor(s):	Sundeen; Joseph E. (Yardley, PA), Dejneka; Tamara (Skillman, NJ)
Assignee:	E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:	06/154,748
Patent Claims:	1. A compound having the formula ##STR14## wherein R.sub.1 is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl; R.sub.2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl; R.sub.3 is alkyl of 3 to 8 carbon atoms, cycloalkyl, aryl, or arylalkyl; and n is an integer of 1 to 20. 2. A compound in accordance with claim 1 wherein R.sub.3 is 2-methylpropyl. 3. A compound in accordance with claim 1 wherein R.sub.1 is hydrogen, acetyl or benzoyl. 4. A compound in accordance with claim 1 wherein n is an integer of 2, 3 or 4. 5. The compound in accordance with claim 1 (.+-.)-2-[(acetylthio)methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]pentanami de. 6. The compound in accordance with claim 1 (.+-.)-2-[(acetylthio)methyl]-4-methyl-N-[2-(1-piperidinyl)ethyl]pentanami de. 7. The compound in accordance with claim 1 2-(mercaptomethyl)-4-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide. 8. The compound in accordance with claim 1 2-(mercaptomethyl)-4-methyl-N-[2-(1-piperidinyl)ethyl]pentanamide. 9. A method for reducing the adverse effects of mammalian collagenase in a mammal host in need thereof, which comprises administering to said mammal an effective amount of a compound having the formula ##STR15## wherein R.sub.1 is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl; R.sub.2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl; R.sub.3 is alkyl of 3 to 8 carbon atoms, cycloalkyl, aryl, or arylalkyl; and n is an integer of 1 to 20. 10. A method in accordance with claim 9 wherein the mammalian host has rheumatoid arthritis.

Details for Patent 4,263,293

Glossary

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.