Claims for Patent: 4,174,389

Summary for Patent: 4,174,389

Title:	Ophthalmic use of collagenase
Abstract:	A method for the selective lysis of collagen fibrils located in the ocular region of a mammal comprising injecting into said ocular region an effective amount of a pharmacologically suitable solution comprising collagenase; and contacting said fibrils with said solution for a period of time sufficient to lyse said fibrils.
Inventor(s):	Cope; Louise A. (Houston, TX)
Assignee:
Application Number:	05/796,807
Patent Claims:	1. A method for the selective lysis of collagen fibrils located in the vitreous of the ocular region of a mammal comprising: injecting intravitreally a small but effective amount of a pharmacologically suitable solution comprising a concentrated amount of collagenase; contacting said fibrils with said solution; flushing the intravitreal region by injecting an effective amount of an inactivator of collagenase solution; and removing said collagenase solution from said intravitreal region before said solution damages other ocular structures not intended to be affected thereby. 2. The method of claim 1 wherein said steps of injecting an inactivator of collagenase solution and removing said collagenase solution are performed substantially simultaneously. 3. A method for the selective lysis of collagen fibrils located in the vitreous of the ocular region of a mammal comprising: preparing a pharmacologically suitable solution comprising collagenase produced from the bacterium Clostridium histolyticum by addmixing a concentrated amount of said collagenase with a solution having a pH of about 7.40 and containing a sufficient amount of calcium ions to activate said collagenase; injecting intravitreally a small but effective amount of said pharmacologically suitable solution comprising a concentrated amount of collagenase; flushing the intravitreal region by injecting an effective amount of an inactivator of collagenase solution; and removing said collagenase from said intravitreal region before said solution damages other ocular structures not intended to be affected thereby. 4. The method of claim 3 wherein said steps of injecting an inactivator of collagenase solution and removing said collagenase solution are performed substantially simultaneously. 5. A method for the selective lysis of collagen fibrils located in the anterior chamber of the ocular region of a mammal comprising: injecting into said anterior chamber a small but effective amount of a pharmacologically suitable solution comprising a concentrated amount of collagenase; contacting said fibrils with said solution; and removing said collagenase solution from said anterior chamber before said solution damages other ocular structures not intended to be affected thereby. 6. The method of claim 5 wherein said collagenase is naturally removed from said anterior chamber.

Details for Patent 4,174,389

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2039-03-29