You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 4,101,673


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 4,101,673
Title: Purification of nutritive oils
Abstract:Parenterally administrable oil-in-water emulsions formed from nutritive oils, such as soybean and sunflower oils, are improved first by treating the nutritive oil with silicic acid to remove undesirable components such as peroxides, pigments, thermal and oxidative decomposition products, certain unsaponifiable matter such as sterols, and polymers. Purification is effected by treating the oil with silicic acid or silica gel either directly, or as a solution thereof in a suitable solvent, such as hexane. Autoxidation of the purified oil is prevented by adding to the purified oil a tocopherol antioxidant, .gamma.-tocopherol being preferred. There is also added a metal scavenging agent such as ascorbyl palmitate.
Inventor(s): Chang; Stephen S. (East Brunswick, NJ)
Assignee: Vitrum AB (Stockholm, SE)
Application Number:05/745,069
Patent Claims:1. A nutritive oil-in-water emulsion suitable for parenteral administration, comprising an oil selected from the group consisting of soybean oil and sunflower oil, an emulsifier for said oil, and water wherein the improvement comprises:

contacting said nutritive oil with an adsorbant selected from the group consisting of silicic acid and silica gel, to substantially remove non-urea-adduct forming esters and unsaponifiable matter from said nutritive oil, recovering said oil from the adsorbant, and subsequently combining the recovered nutritive oil with sterile water and an emulsifier to produce an improved oil-in-water emulsion.

2. A nutritive oil-in-water emulsion as described in claim 1, wherein said oil is mixed with a solvent at the time it is contacted with said adsorbant.

3. A nutritive oil-in-water emulsion as described in claim 1, wherein said emulsion includes a tocopherol and a metal scavenger to inhibit the autoxidation of the emulsified oil.

4. A nutritive oil-in-water emulsion as described in claim 3, wherein said oil recovered from said adsorbant is sunflower oil and contains no more than about 0.29% of non-urea-adduct-forming esters, and contains no more than about 0.34% unsaponifiable matter.

5. A nutritive oil-in-water emulsion as described in claim 3, wherein said oil recovered from said adsorbant is soybean oil and contains no more than about 0.35% of non-urea-adduct-forming esters, and contains no more than about 0.15% unsaponifiable matter.

6. A method of purifying a nutritive oil selected from the group consisting of soybean oil and sunflower oil to remove non-urea-adduct forming esters and unsaponifiable matter therefrom, said method comprising contacting said nutritive oil with an adsorbant selected from the group consisting of silicic acid and silica gel to substantially adsorb non-urea-adduct forming esters and unsaponifiable matter contained in said oil on the adsorbant and recovering the thusly purified oil from the adsorbant.

7. A method of purifying a nutritive oil as described in claim 6, wherein said oil is mixed with a solvent at the time it is contacted with said adsorbant.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.