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Last Updated: March 28, 2024

Claims for Patent: 4,025,614


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Summary for Patent: 4,025,614
Title: Substituted 2H-pyran-2,6 (3H)-dione derivatives useful in treatment of allergic reactions
Abstract:Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
Inventor(s): Snader; Kenneth M. (Hatboro, PA), Willis; Chester R. (Kingston, JM)
Assignee: SmithKline Corporation (Philadelphia, PA)
Application Number:05/681,945
Patent Claims:1. A compound of the formula: ##STR5## wherein Y represents sulfamyl, methylsulfonamido, phenylsulfonamido or sulfamido, or a mono-or di-alkali metal salt of said compound.

2. A compound according to claim 1 in which Y is in the 3-position.

3. A compound according to claim 2 in which Y is sulfamyl.

4. A compound according to claim 2 in which Y is sulfamido.

5. A pharmaceutical composition for inhibiting the symptoms of asthma comprising a nontoxic pharmaceutical carrier or diluent and a therapeutically effective amount to produce said inhibition of a compound of the formula: ##STR6## wherein Y represents sulfamyl, methylsulfonamido, phenylsulfonamido or sulfamido, or a mono-or di-alkali metal salt of said compound.

6. A pharmaceutical composition according to claim 5 in the form of a liquid suspension or solution or admixed with a solid diluent for administration by inhalation.

7. A pharmaceutical composition according to claim 5 comprising a solution or suspension of the active ingredient in sterile water.

8. A pharmaceutical composition according to claim 6 in the form of an aerosol formulation.

9. A pharmaceutical composition according to claim 5 in which the pharmaceutical carrier or diluent is a solid.

10. A pharmaceutical composition according to claim 5 in which Y is in the 3-position.

11. A pharmaceutical composition according to claim 10 in which Y is sulfamido.

12. A pharmaceutical composition according to claim 5 in dosage unit form and in which the active ingredient is in an amount of from about 2.5 mg. to about 500 mg. per dosage unit.

13. A method of inhibiting the symptoms of asthma which comprises administering to an animal in need of said inhibition a therapeutically effective amount for producing said inhibition of a compound of the formula: ##STR7## wherein Y represents sulfamyl, methylsulfonamido, phenylsulfonamido or sulfamido, or a mono-or di-alkali metal salt of said compound.

14. The method according to claim 13 in which the active ingredient is administered in a daily dosage regimen of from about 2.5 mg. to about 2000 mg.

15. The method according to claim 13 in which Y is in the 3-position.

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