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Last Updated: March 28, 2024

Claims for Patent: 4,015,009


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Summary for Patent: 4,015,009
Title: Pharmaceutical compositions comprising substituted 3-cinnamoyl-2H-pyran-2,6(3H)-diones
Abstract:Pharmaceutical compositions comprising a substituted 3-cinnamoyl-2H-pyran-2,6(3H)-dione and methods of inhibiting the antigen-antibody reaction by administering said compositions. Certain of the 3-cinnamoyl-2H-pyran-2,6(3H)-diones are novel compounds per se.
Inventor(s): Chakrin; Lawrence William (Haddonfield, NJ), Snader; Kenneth Means (Hatboro, PA), Willis; Chester Rhodes (Kingston, JM)
Assignee: SmithKline Corporation (Philadelphia, PA)
Application Number:05/659,305
Patent Claims:1. A pharmaceutical composition for inhibiting the symptoms of asthma comprising a nontoxic pharmaceutical carrier or diluent and an amount sufficient to produce said inhibition of a compound of the formula: ##STR8## wherein R is hydrogen, methoxy, dimethoxy, hydroxy, methyl, carboxymethyleneoxy, acetamido or 3-acetamido-4-hydroxy.

2. A pharmaceutical composition according to claim 1 in a form suitable for administration by inhalation.

3. A pharmaceutical composition according to claim 1 comprising a solution or suspension of the active ingredient in sterile water.

4. A pharmaceutical composition according to claim 1 in the form of an aerosol formulation.

5. A pharmaceutical composition according to claim 1 in which the pharmaceutical carrier or diluent is a solid.

6. A pharmaceutical composition according to claim 1 in which R is hydroxy, carboxymethyleneoxy or acetamido.

7. A pharmaceutical composition according to claim 6 in which R is hydroxy.

8. A pharmaceutical composition according to claim 7 in which R is p-hydroxy.

9. A pharmaceutical composition according to claim 1 in dosage unit form and in which the active ingredient is in an amount of about 5 mg. to about 500 mg. per dosage unit.

10. The method of inhibiting the symptoms of asthma which comprises administering to an animal in need thereof a therapeutically effective amount for producing said inhibition of a compound of the formula. ##STR9## wherein R is hydrogen, methoxy, dimethoxy, hydroxy, methyl, carboxymethyleneoxy, acetamido or 3-acetamido-4-hydroxy.

11. The method of claim 10 in which the active ingredient is administered in a daily dosage regimen of about 5 mg. to about 2000 mg.

12. The method according to claim 10 in which R is p-hydroxy.

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