Claims for Patent: 4,009,267

Summary for Patent: 4,009,267

Title:	Cross-linked orgotein
Abstract:	Orgotein cross-linked with itself or with non-antigenic injectable serum or tissue protein has a substantially longer half-life in the blood after injection than orgotein.
Inventor(s):	Huber; Wolfgang (Atherton, CA), Saifer; Mark G. (Berkeley, CA), Williams; Lewis D. (Menlo Park, CA)
Assignee:	Diagnostic Data, Inc. (Mountain View, CA)
Application Number:	05/611,658
Patent Claims:	1. A water-soluble, injectable cross-linked orgotein having a molecular weight of up to 500,000, wherein an orgotein molecule is intermolecularly cross-linked by at least one organic bridging group with at least one molecule of a watersoluble, injectable non-antigenic protein, said organic bridging group being formed by the reaction of orgotein or a mixture of orgotein and another water-soluble, injectable non-antigenic protein, with an organic difunctional cross-linking agent. 2. The cross-linked orgotein of claim 1 wherein the orgotein is bovine. 3. The cross-linked orgotein of claim 1 wherein the non-antigenic protein is orgotein. 4. The cross-linked orgotein of claim 3 wherein the orgotein is bovine. 5. The cross-linked orgotein of claim 3 consisting of 1 to 3 cross-linked orgotein molecules. 6. The cross-linked orgotein of claim 1 cross-linked with globulin or albumin molecules. 7. The cross-linked orgotein of claim 6 wherein the non-antigenic protein is serum albumin. 8. The cross-linked orgotein of claim 7 wherein the albumin is human serum albumin. 9. The cross-linked orgotein of claim 6 wherein the orgotein is bovine. 10. The cross-linked orgotein of claim 7 wherein an orgotein molecule is cross-linked with 1 or 2 serum albumin molecules. 11. The cross-linked orgotein of claim 8 cross-linked with one human serum albumin molecule. 12. A pharmaceutical composition having antiinflammatory activity comprising, in admixture with a pharmaceutically acceptable carrier, an antiinflammatorily effective unit dosage amount of the cross-linked orgotein of claim 1.

Details for Patent 4,009,267

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942		2040-01-28
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954		2040-01-28
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976		2040-01-28
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978		2040-01-28