Claims for Patent: 3,963,613

Summary for Patent: 3,963,613

Title:	Blood purification means
Abstract:	A blood purification means whereby blood of a patient to be treated is led around an external circuit connecting to the patient\'s blood stream and is brought into direct or indirect contact with a fumarate solution, and is further brought into direct or indirect contact with an enzymic preparation, which is suitably an aspartase preparation, which catalyzes a reaction of L-aspartic acid formation from fumaric acid and ammonia. The purification means may further include a preliminary stage or stages whereat an unrequired substance in a patient\'s blood is decomposed to a non toxic substance and ammonia subsequently convertable to aspartic acid, and may also include a low molecular sieve means preventing re-entry of aspartic acid produced into the patient\'s blood stream.
Inventor(s):	Chibata; Ichiro (Suita, JA), Tosa; Tetsuya (Kyoto, JA), Mori; Takao (Takatsuki, JA)
Assignee:	Tanabe Seiyaku Co., Ltd. (Osaka, JA)
Application Number:	05/536,641
Patent Claims:	1. A blood purification means comprising a first cannula circuit for transport of blood having both ends which are adapted to be connected to the blood stream of a patient to be treated, a hemodialysis unit having a first dialysate provided in said first circuit, the first dialysate being effected with the blood of said first cannula circuit through a semi-permeable membrane, a second cannula circuit for transport of the first dialysate of said hemodialysis unit having both ends connected to said hemodialysis unit, a dialyzer having a second dialysate provided in said second cannula circuit, the second dialysate containing additions of fumarate and an aspartase preparation and being selectively effected with said first dialysate through a semipermeable membrane which permits diffusion therethrough of ammonia molecules, but not of aspartic acid molecules, and a pump for driving said first dialysate around said second cannula circuit. 2. A blood purification means comprising a first cannula circuit for transport of blood having both ends which are adapted to be connected to the blood stream of a patient to be treated, a hemodialysis unit having a first dialysate provided in said first circuit, the first dialysate containing an asparaginase preparation and being effected with the blood of said first cannula circuit through a semipermeable membrane, a second cannula circuit for transport of the first dialysate of said hemodialysis unit having both ends connected to said hemodialysis unit, a dialyzer having a second dialysate provided in said second cannula, the second dialysate containing additions of fumarate and an asparaginase preparation and being selectively effected with said first dialysate through a semipermeable membrane which permits diffusion therethrough of ammonia molecules, but not of aspartic acid molecules, and a pump for driving said first dialysate around said second cannula circuit.

Details for Patent 3,963,613

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		1993-12-29