Claims for Patent: 10,513,737

Summary for Patent: 10,513,737

Title:	Cancer diagnostics using non-coding transcripts
Abstract:	Disclosed herein, in certain instances, are methods for the diagnosis, prognosis and determination of cancer progression of a cancer in a subject. Further disclosed herein, in certain instances, are methods for determining the treatment modality of a cancer in a subject. The methods comprise expression-based analysis of non-coding targets and coding targets. Further disclosed herein, in certain instances, are probe sets for use in assessing a cancer status in a subject.
Inventor(s):	Davicioni; Elai (La Jolla, CA), Erho; Nicholas George (Vancouver, CA), Vergara Correa; Ismael A. (West Vancouver, CA)
Assignee:	DECIPHER BIOSCIENCES, INC. (San Diego, CA)
Application Number:	14/365,085
Patent Claims:	1. A method of treating prostate cancer in a subject, comprising: (a) obtaining or having obtained an expression level in a sample from a subject for a plurality of targets, wherein the plurality of targets comprises at least two targets selected from the group consisting of SEQ ID NOs: 103, 218, 275, 301, 321, 607, 707, 795, 828 and 832; (b) determining that the subject is at risk of developing metastatic prostate cancer based on said expression level, or determining that the subject is not at risk of developing metastatic prostate cancer based on said expression level; and (c) administering a prostate cancer treatment to the subject if the subject is determined to be at risk of developing metastatic prostate cancer based on said expression level, or monitoring without administering the prostate cancer treatment to the subject if the subject is determined to not be at risk of developing metastatic prostate cancer based on said expression level. 2. The method of claim 1, wherein the treatment is selected from the group consisting of surgery, a chemotherapeutic agent, radiation therapy, a biological therapeutic, cancer vaccine, gene therapy or a combination thereof. 3. The method of claim 2, wherein the treatment is prostatectomy, a chemotherapeutic agent, anti-androgen therapy or a combination thereof. 4. The method of claim 1, wherein the sample is selected from the group consisting of tissue, blood, plasma, serum, urine, a urine supernatant, a urine cell pellet, semen, prostatic secretions and prostate cells. 5. The method of claim 1, wherein said obtaining comprises a method selected from the group consisting of a sequencing technique, a nucleic acid hybridization technique, and nucleic acid amplification technique, and an immunoassay. 6. The method of claim 5, wherein the nucleic acid amplification technique is polymerase chain reaction, reverse transcription polymerase chain reaction, transcription-mediated amplification, ligase chain reaction, strand displacement amplification or nucleic acid sequence-based amplification. 7. The method of claim 1, wherein administering a prostate cancer treatment comprises administering cisplatin, carboplatin, oxaliplatin, mechlorethamine, cyclophosphamide, chlorambucil, ifosfamide, vincristine, vinblastine, vinorelbine, vindesine, paclitaxel, docetaxel, podophyllotoxin, irinotecan, topotecan, amsacrine, etoposide, etoposide phosphate, teniposide, actinomycin, anthracyclines, doxorubicin, daunorubicin, valrubicin, idarubicin, epirubicin, bleomycin, plicamycin, mitomycin, tositumomab, samarium-153-lexidronam, strontium-89 chloride, interferon alpha, interferon beta, interferon gamma, interleukin-2, interleukin 7, interleukin 12, G-CSF, GM-CSF, rituximab, trastuzumab, bacillus Calmette-Guerin (BCG), levamisole, porfimer sodium, mitoxantrone, prednisone, samarium, strontium, finasteride, or dutasteride.

Details for Patent 10,513,737

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989		2031-12-13
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2031-12-13
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998		2031-12-13
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017		2031-12-13
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017		2031-12-13
Genentech, Inc.	HERCEPTIN HYLECTA	trastuzumab and hyaluronidase-oysk	Injection	761106	02/28/2019		2031-12-13