Claims for Patent: 10,479,832
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Summary for Patent: 10,479,832
Title: | Method of treating bone disease |
Abstract: | The disclosure provides compositions and methods comprising a sialoadhesin binding moiety for treating metabolic and genetic bone disease, especially for treating a bone disorder of hyper-resorption of bone and/or enhanced activation of osteoclasts. |
Inventor(s): | Elewaut; Dirk (Heusden, BE), Louagie; Els (Torhout, BE), Juchtmans; Nele (Ghent, BE) |
Assignee: | Universiteit Gent (Ghent, BE) VIB VZW (Ghent, BE) |
Application Number: | 15/129,792 |
Patent Claims: | 1. A pharmaceutical composition comprising: an antibody that specifically binds sialoadhesin (Sn); an agent for treating bone disorders in an amount useful for the
treatment of a bone loss disorder or bone loss disorders in the subject; and a pharmaceutically acceptable carrier and/or excipient.
2. The pharmaceutical composition of claim 1, wherein the antibody antagonizes sialoadhesin-mediated osteoclast fusion. 3. The pharmaceutical of claim 1, wherein the agent for treating bone disorders is selected from the group consisting of estrogens, selective estrogen receptor modulators, alendronate, risedronate, calcitonin, parathyroid hormone, Teriparatide, RANKL inhibitors, cathepsin K inhibitors, integrin inhibitors, src inhibitors, V-ATPase inhibitors, bafilomycin; zoledronic acid, clodronate, tiludronate, pamidronate, etidronate, ibandronate, partial estrogen agonists and antagonists, genistein, daidzein and related phytoestrogens, tamoxifen, bone binding transition metals gallium, thallium, and indium, and inhibitors of chloride channel activity. 4. A pharmaceutical composition comprising: an antibody that specifically binds sialoadhesin (Sn); an agent for treating bone disorders; and a pharmaceutically acceptable carrier and/or excipient. 5. The pharmaceutical of claim 4, wherein the agent for treating bone disorders is selected from the group consisting of estrogens, selective estrogen receptor modulators, alendronate, risedronate, calcitonin, parathyroid hormone, Teriparatide, RANKL inhibitors, cathepsin K inhibitors, integrin inhibitors, src inhibitors, V-ATPase inhibitors, bafilomycin; zoledronic acid, clodronate, tiludronate, pamidronate, etidronate, ibandronate, partial estrogen agonists and antagonists, genistein, daidzein and related phytoestrogens, tamoxifen, bone binding transition metals gallium, thallium, and indium, and inhibitors of chloride channel activity. |
Details for Patent 10,479,832
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Nps Pharmaceuticals, Inc. | NATPARA | parathyroid hormone | For Injection | 125511 | 01/23/2015 | ⤷ Try a Trial | 2034-03-31 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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