Claims for Patent: 10,392,413

Summary for Patent: 10,392,413

Title:	Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
Abstract:	The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn\'s disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.2\', R.sub.3, R.sub.4, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Q, and n are described herein.
Inventor(s):	Lewis; Jason Gustaf (Castro Valley, CA), Leadbetter; Michael Robert (San Leandro, CA), Caldwell; Jeremy (Menlo Park, CA), Dragoli; Dean (Los Altos, CA), Bell; Noah (Los Angeles, CA), Jacobs; Jeffrey W. (San Mateo, CA), Finn; Patricia (San Leandro, CA), Jain; Rakesh (Danville, CA), Chen; Tao (Palo Alto, CA), Siegel; Matthew (Menlo Park, CA)
Assignee:	ARDELYX, INC. (Fremont, CA)
Application Number:	15/382,872
Patent Claims:	1. A compound of Formula (I'): ##STR00871## or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein: Q is C.dbd.(O), --CH.sub.2--, --NR.sub.5-- or --O--; when Q is C.dbd.(O) then Q.sub.1 is --NR.sub.5--, when Q is --NR.sub.5-- or --O-- then Q.sub.1 is --CH.sub.2--, or when Q is --CH.sub.2-- then Q.sub.1 is --O(CH.sub.2).sub.0-1-- or --NR.sub.5--; X.sub.1 is CR.sub.6 or N; X.sub.2 is CR.sub.7 or N; X.sub.3 is CR.sub.8 or N; X.sub.4 is CR.sub.9 or N; Y is CR.sub.b or N; R.sub.a and R.sub.b are each independently H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, or halogen; R.sub.1 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, halogen, --S(O).sub.p(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, or --O-heterocycloalkyl, wherein the alkyl, alkoxy, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, (C.sub.1-C.sub.4) alkoxy, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.4) alkyl, and --N((C.sub.1-C.sub.4) alkyl).sub.2; or R.sub.1 and R.sub.a together with the carbon atoms to which they are attached form a heterocycloalkyl; or R.sub.1 and R.sub.3, when on adjacent atoms, together with the carbon atoms to which they are attached form a heterocycloalkyl optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, and halogen; R.sub.2 is (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, or (C.sub.1-C.sub.6) haloalkoxy; R.sub.2' is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, or (C.sub.1-C.sub.6) haloalkoxy; or R.sub.2 and R.sub.2' together with the carbon atom to which they are attached form a (C.sub.3-C.sub.8) cycloalkyl or heterocycloalkyl; each R.sub.3 is independently, at each occurrence, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, halogen, --S(O).sub.p(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, or --O-heterocycloalkyl, wherein the alkyl, alkoxy, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, (C.sub.1-C.sub.4) alkoxy, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.4) alkyl, and --N((C.sub.1-C.sub.4) alkyl).sub.2; or R.sub.1 and R.sub.3 together with the carbon atoms to which they are attached form a heterocycloalkyl optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, and halogen; R.sub.4 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --OH, --NH.sub.2, CN, --S(O).sub.m(C.sub.1-C.sub.6) alkyl, --NH(C.sub.1-C.sub.4) alkyl, or --N((C.sub.1-C.sub.4) alkyl).sub.2; each R.sub.5 is independently H, (C.sub.1-C.sub.6) alkyl, --C(O)NR.sub.10R.sub.11, --C(O)(C.sub.1-C.sub.6) alkyl, or --C(O)O(C.sub.1-C.sub.6) alkyl; each R.sub.6 and R.sub.9 is independently H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --OH, --NH.sub.2, CN, --S(O).sub.o(C.sub.1-C.sub.6) alkyl, --NH(C.sub.1-C.sub.4) alkyl, or --N((C.sub.1-C.sub.4) alkyl).sub.2; each R.sub.7 and R.sub.8 is independently H, (C.sub.1-C.sub.8) alkenyl, (C.sub.1-C.sub.8) alkynyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, (C.sub.3-C.sub.8) cycloalkenyl, heterocycloalkyl, --OH, --NH.sub.2, --S(O).sub.qNH.sub.2, --S(O).sub.qOH, CN, or (C.sub.1-C.sub.18) alkyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.18) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.q--, --C(O)--, --C(CH.sub.2)--, or --C(NH)--, provided that when any two methylene in the alkyl is replaced, then two --O--, two --S(O).sub.q--, or two --NR.sub.13-- and --O-- and --NR.sub.13-- are not contiguous, wherein the alkyl is optionally substituted with one or more R.sub.12, and wherein the cycloalkyl and cycloalkenyl are optionally substituted with one or more R.sub.13; R.sub.10 and R.sub.11 are each independently H or (C.sub.1-C.sub.6) alkyl optionally substituted with one or more substituent independently selected from the group consisting of --NH.sub.2 and OH; R.sub.12 is D, --OH, halogen, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, --C(O)OH, --OC(O)(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl, heteroaryl, or R.sub.17, wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, halogen, and R.sub.14; R.sub.13 is H, --OH, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl, heteroaryl, or (C.sub.1-C.sub.12) alkyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.12) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl is replaced, then O and N are not contiguous and wherein the alkyl is optionally substituted with one or more R.sub.15, and wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of --OH, --C(O)OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, and --N((C.sub.1-C.sub.6) alkyl).sub.2; R.sub.14 is (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, --O-heterocycloalkyl, (C.sub.1-C.sub.12) alkyl or (C.sub.2-C.sub.12) alkenyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.12) alkyl and the (C.sub.2-C.sub.12) alkenyl are optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl and alkenyl are optionally substituted with one or more R.sub.15, and the cycloalkyl and heterocycloalkyl are optionally substituted with one or more R.sub.16; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form C.dbd.(O); or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atoms to which they are attached form a (C.sub.3-C.sub.8) cycloalkyl or heterocycloalkyl optionally substituted with one or more R.sub.13; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form a (C.sub.3-C.sub.8) spirocycloalkyl or a spiroheterocycloalkyl optionally substituted with one or more R.sub.13; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form a (C.sub.6-C.sub.10) aryl or heteroaryl optionally substituted with one or more R.sub.13; R.sub.15 is --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl or heteroaryl, wherein the (C.sub.3-C.sub.8) cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, --C(O)OH, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and oxo; R.sub.16 is --OH, --C(O)OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, (C1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, --O-heterocycloalkyl, (C.sub.6-C.sub.10) aryl or heteroaryl, wherein the (C.sub.3-C.sub.8) cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, --C(O)OH, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and oxo; R.sub.17 is (C.sub.1-C.sub.18) alkyl or (C.sub.2-C.sub.18) alkenyl, wherein 0 to 8 methylene of the (C.sub.1-C.sub.18) alkyl and the (C.sub.2-C.sub.18) alkenyl are optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl and alkenyl are optionally substituted with one or more R.sub.18; R.sub.18 is R.sub.19, (C.sub.6-C.sub.10) aryl, or heteroaryl optionally substituted with one or more R.sub.21; R.sub.19 is (C.sub.1-C.sub.18) alkyl wherein 0 to 8 methylene of the (C.sub.1-C.sub.18) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl is optionally substituted with one or more R.sub.20; R.sub.20 is (C.sub.6-C.sub.10) aryl or heteroaryl optionally substituted with one or more R.sub.21; R.sub.21 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, or halogen; or two R.sub.21 together when on adjacent atoms form a cycloalkyl or heterocycloalkyl optionally substituted with one or more R.sub.22, R.sub.22 is --C(O)NH.sub.2, --C(O)NH(C.sub.1-C.sub.6) alkyl, --C(O)N((C.sub.1-C.sub.6) alkyl).sub.2, --C(O) (C.sub.3-C.sub.7) cycloalkyl, or --C(O)heterocycloalkyl, wherein the cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of --OH and CN; each m, o, p, q, and r is independently, at each occurrence, 0, 1, or 2; and n is 0, 1, or 2. 2. The compound of claim 1, wherein Q is --NH-- or --O--. 3. The compound of claim 1, wherein R.sub.3 is halogen. 4. The compound of claim 1, wherein X.sub.1 is CR.sub.6 and R.sub.6 is H or halogen. 5. The compound of claim 1, wherein (i) X.sub.2 is CR.sub.7 and R.sub.7 is H or halogen; or (ii) X.sub.2 is N. 6. The compound of claim 1, wherein X.sub.3 is CR.sub.8. 7. The compound of claim 1, wherein X.sub.4 is N. 8. The compound of claim 1, wherein n is 0 or 1. 9. The compound of claim 1, wherein: Q is-NR.sub.5-- or --O--; Q.sub.1 is --CH.sub.2--; X.sub.1 is CR.sub.6 or N; X.sub.2 is CR.sub.7 or N; X.sub.3 is CR.sub.8 or N; X.sub.4 is CR.sub.9 or N; Y is CH; R.sub.a is H; R.sub.1 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, halogen, --S(O).sub.p(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, or --O-heterocycloalkyl, wherein the alkyl, alkoxy, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, (C.sub.1-C.sub.4) alkoxy, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.4) alkyl, and --N((C.sub.1-C.sub.4) alkyl).sub.2; R.sub.2 and R.sub.2' are each independently (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, or (C.sub.1-C.sub.6) haloalkoxy; or R.sub.2 and R.sub.2' together with the carbon atom to which they are attached form (C.sub.3-C.sub.8) cycloalkyl or heterocycloalkyl; each R.sub.3 is independently, at each occurrence, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, halogen, --S(O).sub.p(C1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, or --O-heterocycloalkyl, wherein the alkyl, alkoxy, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, (C.sub.1-C.sub.4) alkoxy, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.4) alkyl, and --N((C.sub.1-C.sub.4) alkyl).sub.2; R.sub.4 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --OH, --NH.sub.2, CN, --S(O).sub.m(C.sub.1-C.sub.6) alkyl, --NH(C.sub.1-C.sub.4) alkyl, or --N((C.sub.1-C.sub.4) alkyl).sub.2; R.sub.5 is H, (C.sub.1-C.sub.6) alkyl, --C(O)NR.sub.10R.sub.11, --C(O)(C.sub.1-C.sub.6) alkyl, or --C(O)O(C.sub.1-C.sub.6) alkyl; each R.sub.6 and R.sub.9 is independently H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --OH, --NH.sub.2, CN, --S(O).sub.o(C.sub.1-C.sub.6) alkyl, --NH(C.sub.1-C.sub.4) alkyl, or --N((C.sub.1-C.sub.4) alkyl).sub.2; each R.sub.7 and R.sub.8 is independently H, (C.sub.1-C.sub.8) alkenyl, (C.sub.1-C.sub.8) alkynyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, (C.sub.3-C.sub.8) cycloalkenyl, heterocycloalkyl, --OH, --NH.sub.2, --S(O).sub.qNH.sub.2, --S(O).sub.qOH, CN, or (C.sub.1-C.sub.18) alkyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.18) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.q--, --C(O)--, --C(CH.sub.2)--, or --C(NH)--, provided that when any two methylene in the alkyl is replaced, then two --O--, two --S(O).sub.q--, or two --NR.sub.13-- and --O-- and --NR.sub.13-- are not contiguous, wherein the alkyl is optionally substituted with one or more R.sub.12, and wherein the cycloalkyl and cycloalkenyl are optionally substituted with one or more R.sub.13; R.sub.10 and R.sub.11 are each independently H or (C.sub.1-C.sub.6) alkyl optionally substituted with one or more substituent independently selected from the group consisting of --NH.sub.2 and OH; R.sub.12 is --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, --C(O)OH, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl, or heteroaryl, wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and R.sub.14; R.sub.13 is H, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl, heteroaryl, or (C.sub.1-C.sub.12) alkyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.12) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl is replaced, then O and N, are not contiguous and wherein the alkyl is optionally substituted with one or more R.sub.15, and wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of --OH, --C(O)OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, and --N((C.sub.1-C.sub.6) alkyl).sub.2; R.sub.14 is (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, --O-heterocycloalkyl, (C.sub.1-C.sub.12) alkyl or (C.sub.2-C.sub.12) alkenyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.12) alkyl and the (C.sub.2-C.sub.12) alkenyl are optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl and alkenyl are optionally substituted with one or more R.sub.15, and the cycloalkyl and heterocycloalkyl are optionally substituted with one or more R.sub.16; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form C.dbd.(O); or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atoms to which they are attached form a (C.sub.3-C.sub.8) cycloalkyl or heterocycloalkyl optionally substituted with one or more R.sub.13; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form a (C.sub.3-C.sub.8) spirocycloalkyl or a spiroheterocycloalkyl optionally substituted with one or more R.sub.13; R.sub.15 is --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl or heteroaryl, wherein the (C.sub.3-C.sub.8) cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, --C(O)OH, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and oxo; R.sub.16 is --OH, --C(O)OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, --O-heterocycloalkyl, (C.sub.6-C.sub.10) aryl or heteroaryl, wherein the (C.sub.3-C.sub.8) cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, --C(O)OH, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and oxo; each m, o, p, q, and r is independently, at each occurrence, 0, 1, or 2; and n is 0, 1, or 2. 10. The compound of claim 1, having a Formula selected from the group consisting of: ##STR00872## ##STR00873## ##STR00874## ##STR00875## ##STR00876## ##STR00877## 11. The compound of claim 1, selected from the group consisting of: 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)methyl]cy- clopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(propan-2-yloxy)phenyl]pyridin-3-y- l}cyclopropan-1-amine; 1-[4-(2-cyclopropoxy-5-fluorophenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)- methyl]cyclopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-[4-(2-methoxyphenyl)pyridin-3-yl]cyclopr- opan-1-amine; 1-[4-(2-cyclobutoxyphenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)methyl]cyc- lopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-[4-(2-methylphenyl)pyridin-3-yl]cyclopro- pan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(methylsulfanyl)phenyl]pyridin-3-y- l}cyclopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]pyri- din-3-yl}cyclopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-[4-(2-ethylphenyl)pyridin-3-yl]cycloprop- an-1-amine; 1-[4-(2-cyclopropylphenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)methyl]cyc- lopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(trifluoromethoxy)phenyl]pyridin-3- -yl}cyclopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(methoxymethyl)phenyl]pyridin-3-yl- }cyclopropan-1-amine; 1-(4-{2-[(tert-butoxy)methyl]phenyl}pyridin-3-yl)-N-[(2,5-dichlorophenyl)- methyl]cyclopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-(4-phenylpyridin-3-yl)cyclopropan-1-amin- e; N-[(2,5-dichlorophenyl)methyl]-1-[4-(2-ethoxy-4,5-difluorophenyl)pyridi- n-3-yl]cyclopropan-1-amine; 1-[4-(2-chlorophenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)methyl]cyclopro- pan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-[4-(2-fluorophenyl)pyridin-3-yl]cyclopro- pan-1-amine; 1-[4-(2-cyclopropoxy-4-fluorophenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)- methyl]cyclopropan-1-amine; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-y- l}cyclopropan-1-amine; 2-{2-[3-(1-{[(2,5-dichlorophenyl)methyl]amino}cyclopropyl)pyridin-4-yl]ph- enoxy}propan-1-ol; N-[(2,5-dichlorophenyl)methyl]-1-{4-[2-(oxolan-3-yloxy)phenyl]pyridin-3-y- l}cyclopropan-1-amine; (3R,4R)-4-{2-[3-(1-{[(2,5-dichlorophenyl)methyl]amino}cyclopropyl)pyridin- -4-yl]phenoxy}oxolan-3-ol; N-{[2-chloro-5-(methylsulfanyl)phenyl]methyl}-1-[4-(2-cyclopropoxyphenyl)- pyridin-3-yl]cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(2,5-dimethylphenyl)methyl]cy- clopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{[3-methyl-6-(methylsulfanyl)p- yridin-2-yl]methyl}cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(2,3-dichlorophenyl)methyl]cy- clopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(trimethylpyrazin-2-yl)methyl- ]cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(2,4-dichlorophenyl)methyl]cy- clopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(4-methoxy-2,5-dimethylphenyl- ) methyl]cyclopropan-1-amine; N-{[5-chloro-2-(trifluoromethyl)phenyl]methyl}-1-[4-(2-cyclopropoxyphenyl- )pyridin-3-yl]cyclopropan-1-amine; N-[(2-chloro-5-cyclopropylphenyl)methyl]-1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropan-1-amine; N-{[2-chloro-5-(trifluoromethyl)phenyl]methyl}-1-[4-(2-cyclopropoxyphenyl- )pyridin-3-yl]cyclopropan-1-amine; N-[(2-chloro-5-methylphenyl)methyl]-1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropan-1-amine; N-[(5-chloro-2-methylpyridin-4-yl)methyl]-1-[4-(2-cyclopropoxyphenyl)pyri- din-3-yl]cyclopropan-1-amine; N-[(3-chloro-6-methylpyridin-2-yl)methyl]-1-[4-(2-cyclopropoxyphenyl)pyri- din-3-yl]cyclopropan-1-amine; N-[(3-chloro-5-fluoro-4-methoxy-2-methylphenyl)methyl]-1-[4-(2-cyclopropo- xyphenyl)pyridin-3-yl]cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{[2-methyl-5-(trifluoromethyl)- phenyl]methyl)}cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{[4-methoxy-2-methyl-5-(propan- -2-yl)phenyl]methyl}cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{[3-methyl-5-(methylsulfanyl)p- yridin-2-yl]methyl}cyclopropan-1-amine; N-[(5-chloro-2-methylphenyl)methyl]-1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{[2-methyl-5-(methylsulfanyl)p- yridin-4-yl]methyl}cyclopropan-1-amine; N-[(5-chloro-2-methanesulfonylphenyl)methyl]-1-[4-(2-cyclopropoxyphenyl)p- yridin-3-yl]cyclopropan-1-amine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(3,5-dichlorophenyl)methyl]cy- clopropan-1-amine 3-{1-[(2,5-dichlorophenyl)methoxy]cyclopropyl}-4-(2-methoxyphenyl)pyridin- e; 4-(2-cyclopropoxyphenyl)-3-{1-[(2,5-dichlorophenyl)methoxy]cyclopropyl}- pyridine; 4-(2-cyclopropoxyphenyl)-3-{1-[(2,3-dichlorophenyl)methoxy]cyclo- propyl}pyridine; 4-(2-cyclopropoxyphenyl)-3-{1-[(2,4-dichlorophenyl)methoxy]cyclopropyl}py- ridine; 4-(2-cyclobutoxyphenyl)-3-{1-[(2,5-dichlorophenyl)methoxy]cyclopro- pyl}pyridine; 3-{1-[(2,5-dichlorophenyl)methoxy]cyclopropyl}-4-(2-fluorophenyl)pyridine- ; 3-(1-{[5-chloro-2-(trifluoromethyl)phenyl]methoxy}cyclopropyl)-4-(2-cycl- opropoxyphenyl) pyridine; 3-(1-{[2-chloro-5-(trifluoromethyl)phenyl]methoxy}cyclopropyl)-4-(2-cyclo- propoxyphenyl) pyridine; 3-{1-[(2-chloro-5-cyclopropylphenyl)methoxy]cyclopropyl}-4-(2-cyclopropox- yphenyl)pyridine; 3-{1-[(2-chloro-5-methylphenyl)methoxy]cyclopropyl}-4-(2-cyclopropoxyphen- yl)pyridine; 3-{1-[(5-chloro-2-methylphenyl)methoxy]cyclopropyl}-4-(2-cyclopropoxyphen- yl)pyridine; 4-(2-cyclopropoxyphenyl)-3-{1-[(3,5-dichlorophenyl)methoxy]cyclopropyl}py- ridine; 1-{1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}-1-[(2,5-di- chlorophenyl)methyl]urea; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-[(2,5-dichlorophenyl)methyl]-N- -methylcyclopropan-1-amine; 4-(2-cyclopropoxyphenyl)-3-{3-[(2,5-dichlorophenyl)methoxy]oxetan-3-yl}py- ridine; 1-(5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropyl}amino)methyl]phenyl}pentyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}pentanoic acid; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanam- ide; 4-[(4-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropyl}amino)methyl]phenyl}butyl)[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]carbamoyl]butanoic acid; 1-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)phenyl]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]urea; (2R,3R,4R,5S)-6-({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)py- ridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}amino)hexane-1,2,3,4,5-pentol; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]oxane- -4-carboxamide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]aceta- mide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propoxy}methyl)phenyl]butyl}-2-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]propanamide; 3-(benzenesulfonyl)-N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyr- idin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]propanamide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-2-hydroxy-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]acetamide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-2-methoxy-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]acetamide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propa- namide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropoxy}methyl)phenyl]butyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]butanamide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-3-methoxy-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]propanamide; 1-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-3-(2-methoxyethyl)-1-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]urea; (5S)-3-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propoxy}methyl) phenyl]butyl}-5-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-1,3-oxazolidin-2-o- ne; (2S)-4-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropoxy}methyl) phenyl]butyl}-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-1,4-oxazepan-5-one- ; 1-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl)phenyl]butyl}-3-methyl-1-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]- cyclopropoxy}methyl)phenyl]butyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]formamide; (2R,3S,4R,5R)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(4-hydroxy- butyl)hexanamide; (2S,3S,4R,5S)--N-(carbamoylmethyl)-N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopr- opoxyphenyl) pyridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxyhexa- namide; (2R,3S,4R,5R)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)p- yridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(6-- hydroxyhexyl)hexanamide; (2R,3S,4R,5R)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(2-sulfamo- ylethyl)hexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-[2-(2-hydr- oxyethoxy)ethyl]hexanamide; 1-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-1-[2-(2-hydroxyethoxy)ethyl]-3-[(2S,3R,4R,5R)-2,3,- 4,5,6-pentahydroxyhexyl]urea; 2-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamido- }acetic acid; 2-(4-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) phenyl]pentanoyl}piperazin-1-yl)acetic acid; 2-(4-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) phenyl]pentanoyl}piperazin-1-yl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]acetamide; 2-[4-(2-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) phenyl]pentanamido})ethyl)piperazin-1-yl]acetic acid; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-1-{4-[(2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexyl]piperazin-1- -yl}pentan-1-one; (2S,3S,4R,5R,6S)-6-({5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]pentanamido}methyl)-3,4,5-trihydroxyoxa- ne-2-carboxylic acid; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-3-ethyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan- -2-yl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-1-ethyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-1-(2-hydroxyethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]urea; 2-(4-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) phenyl]pentanoyl}piperazin-1-yl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]acetamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-{2-[4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbam- oyl}methyl)piperazin-1-yl]ethyl)}pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-{2-[4-({methyl[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- carbamoyl}methyl)piperazin-1-yl]ethyl}pentanamide; 4-(2-carboxyethyl)-4-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyri- din-3-yl]cyclopropoxy}methyl)phenyl]pentanamido})heptanedioic acid; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-1-{4-[(2S,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-{[(2S,3R,4S,5R,6- R)-3,4,5-trihydroxy-6-(hydroxy-methyl)oxan-2-yl]oxy}hexyl]piperazin-1-yl}p- entan-1-one; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-{[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-- yl]methyl}pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(2-hydroxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]pentanamide; (2R,3R,4S,5R)-2-[({4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)-2-methylphenyl]butyl}carbamoyl)amino]-3,4,5,6-tetra- hydroxyhexanoic acid; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methylphenyl]butyl}-3-(2-hydroxyethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]urea; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-ethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentan- amide; 3-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl)-2-methylphenyl]butyl}-1-{[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6- -(hydroxymethyl)oxan-2-yl]methyl}urea; (2S,3S,4R,5R,6S)-6-{[({4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin- -3-yl]cyclopropoxy}methyl)-2-methylphenyl]butyl}carbamoyl)amino]methyl}-3,- 4,5-trihydroxyoxane-2-carboxylic acid; 2-(2-{2-[({4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropoxy}methyl)-2-methylphenyl]butyl}carbamoyl)amino]acetamido}acetamido)ac- etic acid; (2S)-2-[(2S)-2-[(2S)-2-[({4-[5-chloro-4-({1-[4-(2-cyclopropoxyp- henyl)pyridin-3-yl]cyclopropoxy}methyl)-2-methylphenyl]butyl}carbamoyl)ami- no]propanamido]propanamido]propanoic acid; (2S)-5-carbamimidamido-2-[({4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)py- ridin-3-yl]cyclopropoxy}methyl)-2-methylphenyl]butyl}carbamoyl)amino]penta- noic acid; N-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl)-2-methyl-phenyl]butyl}-4-[(2S,3R,4S,5R)-2,3,4,5,6-pentahy- droxyhexyl]piperazine-1-carboxamide; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-1-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-1-(2-methoxyethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-1-[2-(2-hydroxyethoxy)ethyl]-3-[(2S,3R,4R,5R- )-2,3,4,5,6-pentahydroxyhexyl]urea; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-1-(5-hydroxypentyl)-3-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]urea; (2R)-6-amino-2-[({4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)-2-methylphenyl]butyl})carbamoyl)amino]hexanoic acid; N-benzyl-5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) phenyl]-N-[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-methyl-N-(2-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydrox- ymethyl)oxan-2-yl]oxy}ethyl) pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(2,3-dihydroxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2R)-2-hydroxybutyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2R)-2-hydroxy-3-methoxypropyl]-N-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S)-2-hydroxy-3-methoxypropyl]-N-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]pentanamide; N-benzyl-5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(2-methoxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-(propan-2-y- l)pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-propylpenta- namide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropoxy}methyl)phenyl]-N-(2-methanesulfonylethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(oxan-4-yl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- pentanamide; (2S,3S,4R,5S)--N-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)-2-methylphenyl]butyl}-2,3,4,5,6-pentahydroxy-N-methy- lhexanamide; 5-{2,5-dichloro-4-[({1-[4-(2-methoxyphenyl)pyridin-3-yl]cyclopropyl}amino- )methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide; 5-{2,5-dichloro-4-[({1-[4-(2-methoxyphenyl)pyridin-3-yl]cyclopropyl}amino- )methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pent- anamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propoxy}methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentan- amide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)phenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]pentanamide; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]pentanamide; 1-(4-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- yl}amino)methyl]phenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]urea; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)phenyl]-2-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N,2-dimethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]p- entanamide; 1-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea; 5-{5-chloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]-2-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pen- tanamide; 5-{5-chloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino)methyl]-2-methylphenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-2,2-dimethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]p- entanamide; 5-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl)-2-methyl-phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanam- ide; 5-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)-2-methyl-phenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]pentanamide; 1-(4-{4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)meth- yl]-2,5-dimethyl-phenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]urea; 5-{4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)- methyl]-2,5-dimethyl-phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- pentanamide; 5-{4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -2,5-dimethyl-phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]pentanamide; 1-{4-[4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-2,- 5-dimethylphenyl]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea; 1-(4-{5-chloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]-2-methylphenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]urea; 2-{2-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]ethoxy}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]prop- anamide; (2R,3R,4S,5R)-2-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)p- yridin-3-yl]cyclopropoxy}methyl)phenyl]pentanamido}-3,4,5,6-tetrahydroxyhe- xanoic acid; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-- 3-yl]pentanamide; 2-{2-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]ethoxy}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]propanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl]pentanami- de; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]pentanoic acid; 1-(1-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) phenyl]pentanoyl}piperidin-4-yl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-(1-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropoxy}methyl) phenyl]pentanoyl}piperidin-4-yl)-3-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]urea; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-(morpholin-4-yl)hex- an-2-yl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexan- amide; 1-(5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropyl}amino)methyl]phenyl}pentyl)-3-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-p- entahydroxyhexyl]urea; 2-{[(2S,3R,4S,5R)-2-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]pentanamido}-3,4,5,6-tetrahydroxyhexyl]- (methyl)amino}acetic acid; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(2S,3R,4S,5R)-1-(dimethylamino)-3,4,5,6-tetrahydroxyhexa- n-2-yl]pentanamide; 4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl)-2-methyl-phenyl]butan-1-amine; 1-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)-2-methyl-phenyl]butyl}-3-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]urea; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N,N-bis(2-{[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carba- moyl}ethyl)pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N,N-bis(2-{methyl[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]carbamoyl}ethyl)pentanamide; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}-N,N-bis(2-{[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]carbamoyl}ethyl) pentanamide; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}-N,N-bis(2-{methyl[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]carbamoyl}ethyl) pentanamide; (2S,3S,4R,5S)--N-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)-2-methylphenyl]butyl}-2,3,4,5,6-pentahydroxyhexanami- de; (2S,3S,4R,5S)-6-[(1-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)py- ridin-3-yl]cyclopropoxy}methyl)phenyl]pentanoyl}piperidin-4-yl)amino]-2,3,- 4,5-tetrahydroxyhexanoic acid; 1-[4-(2,5-dichloro-4-{[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cyclo- propyl)amino]methyl}phenyl)butyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-[4-(2,5-dichloro-4-{[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-- 3-yl}cyclopropyl)amino]methyl}phenyl)butyl]-3-methyl-3-[(2S,3R,4R,5R)-2,3,- 4,5,6-pentahydroxyhexyl]urea; (2S,3S,4R,5S)--N-{4-[5-chloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)-2-methylphenyl]butyl}-2,3,4,5-tetrahydroxy-6-(morpho- lin-4-yl)hexanamide; 5-(2,5-dichloro-4-{[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cyclopro- pyl)amino]methyl}phenyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]pentanamide; 3-(5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- yl}amino) methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pent- anamido)propanoic acid; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5-tetrahydroxy-6-(morpholin-4- -yl)hexanamide; (2S,3S,4R,5S)-6-[(3-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]-N-methylpentanamido}propyl)amino]-2,3,- 4,5-tetrahydroxy-hexanoic acid; N-{[(2R,3S,4S,5R,6R)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R- )-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexy- l]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl}-5-[2,5-dichloro-4-({1-[4-(2-cyclo- propoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)phenyl]pentanamide; 4-({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl)phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamo- yl)butanoic acid; 3-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamido- }propanoic acid; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-methylhexa- namide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)p- yridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxyhexana- mide; 2-[({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropoxy}methyl) phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl)methoxy- ]acetic acid; 3-({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl)phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamo- yl)propanoic acid; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5-tetrahydroxy-N-methyl-6-(mo- rpholin-4-yl)hexanamide; 1-(4-{5-chloro-2-methyl-4-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}c- yclopropoxy) methyl]phenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea; 1-(4-{5-chloro-2-methyl-4-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}c- yclopropoxy) methyl]phenyl}butyl)-3-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]urea; 5-{2,5-dichloro-4-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cy- clopropoxy)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]pentanamide; 1-(4-{2,5-dichloro-4-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cyclop- ropoxy)methyl]phenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]u- rea; 1-({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propoxy}methyl)phenyl]butyl}sulfamoyl)-3-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]urea; 2-{[({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl)methyl]- (methyl)amino}acetic acid; 4-({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl)phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamo- yl)-3,3-dimethylbutanoic acid; 2-[({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl)amino]a- cetic acid; 3-[({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl)amino]p- ropanoic acid; 4-[({4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]butyl}[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl)amino]b- utanoic acid; 2-({[(4-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropyl}amino)methyl]phenyl}butyl)[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]carbamoyl]methyl}(methyl)amino) acetic acid; 4-[(4-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- pyl}amino)methyl]phenyl}butyl)[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]c- arbamoyl]-3,3-dimethylbutanoic acid; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-2-methanesulfonyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]acetamide; N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-2-(dimethylamino)-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]acetamide; 1-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]butyl}-1-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl]urea; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl- )pyridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-p- ropylhexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(2-methoxy- ethyl)hexanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[2-(dimethylamino)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]pentanamide; N-(carbamoylmethyl)-5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridi- n-3-yl]cyclopropoxy}methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]pentanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-N-ethyl-2,3,4,5,6-pentahydroxyhexan- amide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)py- ridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(pro- pan-2-yl)hexanamide; (2S,3S,4R,5S)--N-(cyclopropylmethyl)-N-{4-[2,5-dichloro-4-({1-[4-(2-cyclo- propoxyphenyl) pyridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxyhexa- namide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)p- yridin-3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(3-- methoxypropyl)hexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(2-hydroxy- ethyl)hexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-[(2R)-2-hy- droxypropyl]hexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-[(2S)-2-hy- droxypropyl]hexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(oxan-4-yl- )hexanamide; (2S,3S,4R,5S)--N-{4-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]butyl}-2,3,4,5,6-pentahydroxy-N-(3-hydroxy- propyl)hexanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(3-hydroxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(methylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(3-methoxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[(dimethylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]pentanamide; 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-[2-(dimethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-p- entahydroxyhexyl]pentanamide; N-(2-carbamoylethyl)-5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]pentanamide; (2S,3S,4R,5S)--N-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]pentyl}-2,3,4,5,6-pentahydroxy-N-[2-(2-hyd- roxyethoxy)ethyl]hexanamide; 1-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]pentyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea- ; (2S,3S,4R,5S)--N-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin- -3-yl]cyclopropoxy}methyl)phenyl]pentyl}-2,3,4,5,6-pentahydroxy-N-(2-metha- nesulfonylethyl)hexanamide; (2S,3S,4R,5S)--N-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]pentyl}-N-[2-(ethanesulfonyl)ethyl]-2,3,4,- 5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-{5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]pentyl}-2,3,4,5,6-pentahydroxy-N-methylhex- anamide; 5-[4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methy- l)-2,5-dimethylphenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentan- amide; 5-[4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -2,5-dimethylphenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]pentanamide; 5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl)phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide; 5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl)phenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanami- de; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanami- de; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- pentanamide; 5-[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-met- hylphenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide; 5-[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-met- hylphenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanami- de; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)meth- yl]-4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanami- de; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)meth- yl]-4-methylphenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- pentanamide; 1-{4-[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-- methylphenyl]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea; 1-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)meth- yl]-4-methyl-phenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 1-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- urea; N-{[5-(6-aminohexan-2-yl]-2-chlorophenyl}methyl)-1-[4-(2-cyclopropox- yphenyl)pyridin-3-yl]cyclopropan-1-amine; N-({5-[(2S)-6-aminohexan-2-yl]-2-chlorophenyl}methyl)-1-[4-(2-cyclopropox- yphenyl)pyridin-3-yl]cyclopropan-1-amine; N-({5-[(2R)-6-aminohexan-2-yl]-2-chlorophenyl}methyl)-1-[4-(2-cyclopropox- yphenyl)pyridin-3-yl]cyclopropan-1-amine; (5S)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl)phenyl]hexan-1-amine; (5R)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl)phenyl]hexan-1-amine; (5S)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}hexanoic acid; (5R)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}hexanoic acid; 6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl)}heptanoic acid; N-({5-[(2S)-5-aminopentan-2-yl]-2-chlorophenyl}methyl)-1-[4-(2-cyclopropo- xyphenyl)pyridin-3-yl]cyclopropan-1-amine; N-({5-[(2R)-5-aminopentan-2-yl]-2-chlorophenyl}methyl)-1-[4-(2-cyclopropo- xyphenyl)pyridin-3-yl]cyclopropan-1-amine; N-{[5-(5-aminopentan-2-yl)-2-chlorophenyl]methyl}-1-[4-(2-cyclopropoxyphe- nyl)pyridin-3-yl]cyclopropan-1-amine; (5S)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)me- thyl]-4-methylphenyl}hexanoic acid; (5R)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)me- thyl]-4-methylphenyl}hexanoic acid; 1-[(5S)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- pyl}amino)methyl]phenyl}hexyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]urea; 1-[(5R)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]c- yclopropyl}amino)methyl]phenyl}hexyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-methylh- exanamide; N-benzyl-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropyl}amino)methyl]-4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]hexanamide; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanami- de; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}-N-(5-hydroxypentyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[2-(morpholine-4-sulfonyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4- ,5,6-pentahydroxyhexyl]hexanamide; 1-[(5S)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl)phenyl]hexyl]-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl- ]urea; 1-[(5R)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropoxy}methyl)phenyl]hexyl]-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexa- n-2-yl]urea; 1-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}pentyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 1-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}hexyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-- 2-yl]urea; 1-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropyl}amino)methyl]phenyl}hexyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]urea; 1-(6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}heptyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 1-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}hexyl)-1-methyl-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; 1-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}hexyl)-1-[2-(2-hydroxyethoxy)ethyl]-3-[(2S,3R,4R,5R)-2,- 3,4,5,6-pentahydroxyhexyl]urea; 1-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)meth- yl]-4-methylphenyl}pentyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 1-(5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)m- ethyl]-4-methylphenyl}hexyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- urea; 1-[(5R)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl)phenyl]hexyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]urea; 1-[(5S)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropoxy}methyl)phenyl]hexyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]urea; 1-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)phenyl]hexyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 1-{5-[3-(1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-- 4-methylphenyl]hexyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-[2-(2-o- xoimidazolidin-1-yl)ethyl]hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxyhexanamide- ; (2S,3S,4R,5S)--N-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}hexyl)-2,3,4,5,6-pentahydroxyhexanamide- ; (2S,3S,4R,5S)--N-(6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}heptyl)-2,3,4,5,6-pentahydroxyhexanamid- e; (2S,3S,4R,5S)--N-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropyl}amino)methyl]phenyl}hexyl)-2,3,4,5,6-pentahydroxy-N-methyl- hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(2-meth- oxyethyl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(4-hydr- oxybutyl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(3-meth- oxypropyl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(oxan-4- -yl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-[2-(2-h- ydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(oxan-4- -ylmethyl)hexanamide; (2S,3S,4R,5S)--N-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}hexyl)-2,3,4,5,6-pentahydroxy-N-[2-(2-hy- droxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(2-meth- anesulfonylethyl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-N-(4-acetamidobutyl)-2,3,4,5,6-p- entahydroxyhexanamide; (2S,3S,4R,5S)--N-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}hexyl)-2,3,4,5,6-pentahydroxy-N-(2-metha- nesulfonylethyl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(3-meth- anesulfonylpropyl)hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-N-[2-(ethanesulfonyl)ethyl]-2,3,- 4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-[3-(2-o- xopyrrolidin-1-yl)propyl]hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-N-(1,1-dioxo-1.lamda..sup.6-thia- n-4-yl)-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}hexyl)-N-[2-(ethanesulfonyl)ethyl]-2,3,4- ,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(4-meth- anesulfonamidobutyl) hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pentyl)-N-[2-(1,1-dioxo-1.lamda..sup.6,4- -thiomorpholin-4-yl)ethyl]-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}pentyl)-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}hexyl)-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-methylhexanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(2-methoxyethyl)h- exanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino) methyl]-4-methylphenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(3-methoxypropyl)- hexanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(oxan-4-yl)hexana- mide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropyl}amino) methyl]-4-methylphenyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(2-methanesulfony- lethyl) hexanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}pentyl)-N-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-2,- 3,4,5,6-pentahydroxy-hexanamide; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}pentyl)-N-[2-(ethanesulfonyl)ethyl]-2,3,4,5,6-pent- ahydroxy-hexanamide; (2S,3S,4R,5S)--N-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)phenyl]hexyl}-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)phenyl]pentyl}-2,3,4,5,6-pentahydroxy-N-(2-methanesul- fonylethyl)hexanamide; (2S,3S,4R,5S)--N-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)phenyl]pentyl}-N-[2-(ethanesulfonyl)ethyl]-2,3,4,5,6-- pentahydroxyhexanamide; (2S,3S,4R,5S)--N-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)phenyl]pentyl}-N-(1,1-dioxo-1.lamda..sup.6-thian-4-yl- )-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-{5-[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl)-4-methylphenyl]hexyl}-2,3,4,5,6-pentahydroxyhexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl]hexanam- ide; (5S)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hex- anamide; (5R)-5-{(4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropyl}amino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanamide; 6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]heptanamide; (2S,3S,4R,5S)-6-{[1-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropyl}amino)methyl]phenyl}hexanoyl)piperidin-4-yl]amino}-2,3,4,- 5-tetrahydroxyhexanoic acid; 4-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}hexanoyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- piperazine-1-carboxamide; 1-[1-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}hexanoyl)piperidin-4-yl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]urea; 2-[4-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}hexanoyl)piperazin-1-yl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]acetamide; 4-[2-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}hexanamido)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]piperazine-1-carboxamide; 1-{2-[4-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino)methyl]phenyl}hexanoyl)piperazin-1-yl]ethyl}-3-[(2S,3R,4R,5R)-2- ,3,4,5,6-pentahydroxyhexyl]urea; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-{2-[4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carb- amoyl}methyl)piperazin-1-yl]ethyl}hexanamide; (5S)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; (5R)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hex- anamide; (6S)-6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropyl}amino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]heptanamide; (6R)-6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]heptanamide; 6-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hep- tanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino)methyl]phenyl}-N-(2-hydroxyethyl)-N-[(2R,3S,4S,5S)-2,3,4,5,6-pe- ntahydroxyhexyl]hexanamide; N-(carbamoylmethyl)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropyl}amino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(2-methoxyethyl)-N-[(2R,3S,4S,5S)-2,3,4,5,6-pentahydrox- yhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(3-hydroxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]hexanamide; N-(2-carbamoylethyl)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropyl}amino)methyl]phenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[(methylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[2-(dimethylamino)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(3-methoxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(oxan-4-yl)-N-[(2R,3S,4S,5S)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[(dimethylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(3-hydroxy-2,2-dimethylpropyl)-N-[(2R,3S,4S,5S)-2,3,4,5- ,6-pentahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[2-(2-hydroxyethoxy)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-p- entahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[(2R,3S,4S,5S)-2,3,4,5,6-pentahydroxyhexyl]-N-[(1s,4s)-- 4-hydroxycyclohexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[2-(ethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[2-(dimethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(2-methanesulfonylethyl)-N-[(2R,3S,4S,5S)-2,3,4,5,6-pen- tahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-(3-methanesulfonylpropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]hexanamide; 5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]phenyl}-N-[2-(dimethylsulfamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-ethylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanamide; (5S)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)me- thyl]-4-methyl-phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]hexanamide; (5R)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)me- thyl]-4-methyl-phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hex- anamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino- )methyl]-4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-(- propan-2-yl)hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-propylhex- anamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino- )methyl]-4-methylphenyl}-N-(2-hydroxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]hexanamide; N-(carbamoylmethyl)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexa- namide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)- methyl]-4-methylphenyl}-N-(2-methoxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-(3-hydroxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]hexanamide; N-(2-carbamoylethyl)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropyl}amino) methyl]-4-methylphenyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexa- namide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)- methyl]-4-methylphenyl}-N-[(methylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4- ,5,6-pentahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-[2-(dimethylamino)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-(3-methoxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-(oxan-4-yl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-[(dimethylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-[2-(ethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-[2-(dimethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]hexanamide; (5S)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)me- thyl]-4-methyl-phenyl}-N-(2-methanesulfonylethyl)-N-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]hexanamide; (5R)-5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)me- thyl]-4-methyl-phenyl}-N-(2-methanesulfonylethyl)-N-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-(2-methanesulfonylethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]hexanamide; 5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]- -4-methylphenyl}-N-(3-methanesulfonylpropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]hexanamide; 2-[4-(5-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)m- ethyl]-4-methyl-phenyl}hexanoyl)piperazin-1-yl]-N-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]acetamide; 5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl)phenyl]-N-ethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanamide- ; 5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]-N-(2-hydroxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; 5-[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-met- hylphenyl]-N-ethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexanamide- ; 5-[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-me- thylphenyl]-N-(2-hydroxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]hexanamide; N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}pentyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ac- etamide; N-(5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino)methyl]phenyl}hexyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]acetamide; 5-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}-5-hydroxypentyl)-2,3,4,5,6-pentahydroxy- hexanamide; (2S,3S,4R,5S)--N-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropyl}amino)methyl]phenyl}pent-4-en-1-yl)-2,3,4,5,6-pentahydroxyhe- xanamide; (2S,3S,4R,5S)--N-[3-(1-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl- )pyridin-3-yl]cyclopropyl}amino)methyl]phenyl}cyclopropyl)propyl]-2,3,4,5,- 6-pentahydroxyhexanamide; 1-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}pent-4-en-1-yl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]urea; 1-(4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}a- mino)methyl]phenyl}-5-hydroxypentyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]urea; 1-[3-(1-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropy- l}amino)methyl]phenyl}cyclopropyl)propyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]urea; (2S,3S,4R,5S)--N-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino) methyl]-4-methylphenyl}-5-hydroxypentyl)-2,3,4,5,6-pentahydroxyhexanamide- ; 1-(4-{3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)met- hyl]-4-methylphenyl}-5-hydroxypentyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; (2S,3S,4R,5S)--N-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)benzenesulfonamido]butyl}-2,3,4,5,6-pentahydroxyhexan- amide; 1-{4-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]- cyclopropoxy}methyl) benzenesulfonamido]butyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-- yl]urea; 1-{4-[N-ethyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl) benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-1-{4-[N-(propan-2-yl)4-c- hloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)benz- enesulfonamido]butyl}urea; 1-(4-{N-methyl2,4-dichloro-5-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]c- yclopropyl}amino) methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)-N,N-dimethylbenzene-1-sulfonamide; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -N-methylbenzene-1-sulfonamide; 3-(1-{[2-chloro-5-(pyrrolidine-1-sulfonyl)phenyl]methoxy}cyclopropyl)-4-(- 2-cyclopropoxyphenyl)pyridine; 3-(1-{[2-chloro-5-(piperidine-1-sulfonyl)phenyl]methoxy})cyclopropyl)-4-(- 2-cyclopropoxyphenyl)pyridine; (2S,3R,4R,5R)--S-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropoxy}methyl)phenyl]-2,3,4,5,6-pentahydroxyhexane-1-sulfonamido; (2S,3R,4R,5R)--S-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropoxy}methyl)phenyl]-2,3,4,5,6-pentahydroxy-N-methylhexane-1-sulfonam- ido; N-[2-(2-aminoethoxy)ethyl]-4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)py- ridin-3-yl]cyclopropoxy}methyl)benzene-1-sulfonamide; N-[2-(2-aminoethoxy)ethyl]-4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridi- n-3-yl]cyclopropoxy}methyl)-N-methylbenzene-1-sulfonamide; 1-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl]urea; 1-{4-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropoxy}methyl) benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ur- ea; 1-(2-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) benzenesulfonamido]ethoxy}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-(2-{2-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridi- n-3-yl]cyclopropoxy}methyl) benzenesulfonamido]ethoxy}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-{5-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl) benzenesulfonamido]pentyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2- -yl]urea; 1-(2-{2-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin- -3-yl]cyclopropoxy}methyl) benzenesulfonamido]ethoxy}ethyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyh- exan-2-yl]urea; 1-{4-[N-(2-methoxyethyl)4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl)benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]urea; 1-(2-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonamido]ethoxy}ethyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pent- ahydroxyhexan-2-yl]urea; 1-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonamido]pentyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyh- exan-2-yl]urea; 1-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonamido]butyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhe- xan-2-yl]urea; 1-(2-{2-[N-ethyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) benzenesulfonamido]ethoxy}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-{5-[N-(2-methoxyethyl)4-chloro-3-({1-[4-(2-cyclopropoxyphenyl- )pyridin-3-yl]cyclopropoxy}methyl)benzenesulfonamido]pentyl}-3-[(2S,3R,4R,- 5R)-2,3,4,5,6-pentahydroxyhexyl]urea; 1-{5-[N-(2-methoxyethyl)4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl)benzenesulfonamido]pentyl}-3-[(2S,3R,4S,5R)-1,3,4,- 5,6-pentahydroxyhexan-2-yl]urea; 1-{4-[N-(2-hydroxyethyl)4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl)benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]urea; 1-(2-{2-[N-ethyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) benzenesulfonamido]ethoxy}ethyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyh- exan-2-yl]urea; 1-{4-[N-(2-methoxyethyl)4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl)benzenesulfonamido]butyl}-3-[(2S,3R,4S,5R)-1,3,4,5- ,6-pentahydroxyhexan-2-yl]urea; 1-(2-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonyl]piperidin-4-yl}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]urea; 3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-1-[(1r,4r)-4-[4-chloro-3-({- 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)benzenesulfona- mido]cyclohexyl]urea; 3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-1-[(1 s,4s)-4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl)benzenesulfonamido]cyclohexyl]urea; 1-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) benzenesulfonyl]pyrrolidin-3-yl}methyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]urea; 1-(2-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonyl]azetidin-3-yl}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]urea; 1-(4-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonamido]ethyl}cyclohexyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]urea; 1-(3-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonyl]piperazin-1-yl}propyl)-3-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]urea; 1-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) benzenesulfonyl]piperidin-4-yl}methyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]urea; 1-(2-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonyl]piperazin-1-yl}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]urea; 1-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) benzenesulfonyl]piperidin-3-yl}methyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]urea; 1-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]azetidin-3-yl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]urea; 1-{7-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzene-sulfonyl]-7-azaspiro[3.5]nonan-2-yl}-3-[(2S,3R,4R,5R)-2,3,4- ,5,6-pentahydroxyhexyl]urea; 1-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]pyrrolidin-3-yl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]urea; 1-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)benzene-sulfonyl]-2-azaspiro[3.3]heptan-6-yl}-3-[(2S,3R,4R,5R)-2,3,4- ,5,6-pentahydroxyhexyl]urea; 6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl) benzenesulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]hexan- amide; 7-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]heptanamide; 5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl) benzenesulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]penta- namide; 3-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropoxy}methyl) benzenesulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanam- ide; (1R,5S,6S)-3-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropoxy}methyl) benzenesulfonyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-3-azabicyc- lo[3.1.0]hexane-6-carboxamide; (1r,4r)-4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl) benzenesulfonamidomethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]cy- clohexane-1-carboxamide; 1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl) benzenesulfonyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]piperidi- ne-4-carboxamide; 2-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]azetidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]acetamide; 3-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl)benzene-sulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]cyclo- pentane-1-carboxamide; 2-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]piperazin-1-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]acetamide; 2-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]piperidin-4-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]acetamide; (1r,4r)-4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl) benzenesulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]cyclohex- ane-1-carboxamide; 3-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]piperazin-1-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]propanamide; 2-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) benzenesulfonyl]piperidin-4-yl}oxy)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]acetamide; 4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl) benzenesulfonamido]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]bicyc- lo[2.2.2]octane-1-carboxamide; (2E)-3-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl) benzenesulfonyl]azetidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]prop-2-enamide; 2-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)benzene-sulfonyl]azetidin-3-yl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]acetamide; 3-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]azetidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]propanamide; 3-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]piperidin-4-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]propanamide; (2E)-3-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycloprop- oxy}methyl) benzenesulfonyl]pyrrolidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]prop-2-enamide; 3-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]pyrrolidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]propanamide; (2E)-4-{(1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) benzenesulfonyl]azetidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]but-2-enamide; 4-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]azetidin-3-yl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydr- oxyhexyl]butanamide; 2-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) benzenesulfonyl]azetidin-3-yl}oxy)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]acetamide; 2-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)benzene-sulfonyl]pyrrolidin-3-yl}methoxy)-N-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]acetamide; 2-({1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)benzene-sulfonyl]azetidin-3-yl}methoxy)-N-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]acetamide; (2S,3S,4R,5S)--N-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)benzenesulfonamido]butyl}-2,3,4,5,6-pentahydroxy-N-(2- -methanesulfonylethyl) hexanamide; (2S,3S,4R,5S)-2,3,4,5,6-pentahydroxy-N-{4-[N-methyl4-chloro-3-({1-[4-(2-c- yclopropoxy-phenyl)pyridin-3-yl]cyclopropoxy}methyl)benzenesulfonamido]but- yl}hexanamide; (2S,3S,4R,5S)-2,3,4,5,6-pentahydroxy-N-(2-methanesulfonylethyl)-N-{4-[N-m- ethyl-4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}me- thyl)benzenesulfonamido]butyl)}hexanamide; (2S,3S,4R,5S)--N-{4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)benzenesulfonamido]butyl}-2,3,4,5,6-pentahydroxy-N-me- thylhexanamide; (2S,3S,4R,5S)-2,3,4,5,6-pentahydroxy-N-methyl-N-{4-[N-methyl4-chloro-3-({- 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)benzenesulfona- mido]butyl)}hexanamide; (2S,3S,4R,5S)--N-(2-{1-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl)benzenesulfonyl]piperidin-4-yl}ethyl)-2,3,4,5,6-pe- ntahydroxyhexanamide; N-(4-aminobutyl)-4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyc- lopropoxy}methyl)-N-ethylbenzene-1-sulfonamide; 1-(4-{N-methyl4-chloro-3-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cy- clopropoxy)methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]urea; 1-{4-[N-ethyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) benzenesulfonamido]butyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-- yl]urea; 1-{4-[N-methyl4-chloro-5-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)-2-fluorobenzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-- 2,3,4,5,6-pentahydroxyhexyl]urea; 1-{4-[N-methyl2,4-dichloro-5-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cy- clopropoxy}methyl)benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]urea; 1-(4-{N-methyl3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}am- ino)methyl]-4-(trifluoromethyl)benzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-- 2,3,4,5,6-pentahydroxyhexyl]urea; 1-{4-[N-methyl3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}me- thyl)-4-(trifluoromethyl)benzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,- 5,6-pentahydroxyhexyl]urea; 1-(4-{N-methyl3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}am- ino)methyl]-4-(trifluoromethyl)benzenesulfonamido}butyl)-3-[(2S,3R,4S,5R)-- 1,3,4,5,6-pentahydroxyhexan-2-yl]urea; 1-(4-{N-methyl4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-(4-{N-methyl4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropyl}amino) methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyh- exan-2-yl]urea; 1-(4-{N-ethyl4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropyl}amino) methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]urea; 1-(4-{N-methyl4-chloro-5-[({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropyl}amino) methyl]-2-fluorobenzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]urea; 1-(4-{N-methyl4-chloro-5-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-2-fluorobenzenesulfonamido}butyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pent- ahydroxyhexan-2-yl]urea; 1-(4-{N-methyl2,4-dichloro-5-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]c- yclopropyl}amino) methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyh- exan-2-yl]urea; 1-(4-{N-methyl3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}am- ino)methyl]-4-methylbenzenesulfonamido}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-p- entahydroxyhexyl]urea; 1-(4-{N-methyl3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}am- ino)methyl]-4-methylbenzenesulfonamido}butyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-p- entahydroxyhexan-2-yl]urea; 1-{4-[N-methyl3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}me- thyl)-4-methylbenzenesulfonamido]butyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]urea; (2S)-5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl) benzenesulfonamido]-2-{[(2,3,4,5,6-pentahydroxyhexyl)carbamoyl]am- ino}pentanoic acid; (2R)-2-amino-6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) benzenesulfonamido]-N-ethylhexanamide; (2R)-6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl) benzene-sulfonamido]-N-ethyl-2-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]carbamoyl}amino) hexanamide; (2S)-2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl) benzenesulfonamido]-6-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]carbamoyl}amino) hexanoic acid; (2S)-2-amino-6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) benzenesulfonamido]hexanoic acid; (2S)-6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl) benzenesulfonamido]-2-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]carbamoyl}amino) hexanoic acid; (2S)-2-amino-6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl) benzenesulfonamido]-N-ethylhexanamide; (2S)-6-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl) benzenesulfonamido]-N-ethyl-2-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]carbamoyl)}amino)hexanamide; 1-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}pentyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]urea; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyri- din-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-2,3,4,5,6-pentahydrox- y-N-[2-(2-hydroxyethoxy)ethyl]hexanamide; 1-[2-(2-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]sulfanyl}ethoxy)ethyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]urea; 1-(2-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfinyl]ethoxy}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]urea; 1-(2-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfonyl]ethoxy}ethyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]urea; 1-{2-[2-({4-chloro-3-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cyclop- ropoxy)methyl]phenyl}sulfanyl)ethoxy]ethyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]urea; 1-[5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}sulfanyl)pentyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]urea; 5-({6-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl- ]-5-methylpyridin-2-yl}sulfanyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]pentanamide; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{[5-methyl-2-(methylsulfanyl)p- yrimidin-4-yl]methyl}cyclopropan-1-amine; 4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-et- hylphenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]butanamid- e; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl)phenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]butana- mide; N-[5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opyl}amino)methyl]phenyl}sulfanyl)pentyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]acetamide; N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) phenyl]sulfanyl}propyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]acetamide; N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}butyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]acetamide; N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}sulfanyl)propyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]acetamide; N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}sulfanyl)butyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]acetamide; N-[2-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}sulfanyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]acetamide; N-(2-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}ethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]acetamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-methylhexanamide; (2S,3S,4R,5S)--N-[5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)pentyl]-2,3,4,5,6-pentahydroxy- -N-methylhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-met- hylhexanamide; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-2,3,4,5,6-pentahydroxy-N-met- hylhexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-meth- ylhexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-methylhexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-[2-(- 2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(4-h- ydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(oxa- n-4-yl)hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-[3-(- 2-oxopyrrolidin-1-yl)propyl]hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(oxa- n-4-ylmethyl)hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-[2-(- 2-oxoimidazolidin-1-yl)ethyl]hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-[2-- (2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(4-- hydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-[3-- (2-oxopyrrolidin-1-yl)propyl]hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-N-[2-(1,1-dioxo-1.lamda..sup- .6,4-thiomorpholin-4-yl)ethyl]-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(ox- an-4-ylmethyl)hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(3-m- ethanesulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-N-[2-(1,1-dioxo-1.lamda..sup.- 6,4-thiomorpholin-4-yl)ethyl]-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(3-methanesulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-[2-(2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(4-hydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(oxan-4-yl)hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-[3-(2-oxopyrrolidin-1-yl)propyl]hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-N-[2-(1,1-dioxo-1.lamd- a..sup.6,4-thiomorpholin-4-yl)ethyl]-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-[2-(2-oxoimidazolidin-1-yl)ethyl]hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(3-methanesulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-[2-(2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(4-hydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(oxan-4-yl)hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(oxan-4-ylmethyl)hexanamide; (2S,3S,4R,5S)--N-(3-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(3-- methanesulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-(3-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-[2-- (2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-(3-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(4-- hydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-(3-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(ox- an-4-yl)hexanamide; (2S,3S,4R,5S)--N-(4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(4-h- ydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-[2-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)ethyl]-2,3,4,5,6-pentahydroxy-- N-methylhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-[2-- (2-oxoimidazolidin-1-yl)ethyl]hexanamide; (2S,3S,4R,5S)--N-[3-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy-N-(3-metha- nesulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-[3-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy-N-[2-(2-hy- droxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-[3-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy-N-(4-hydro- xybutyl) hexanamide; (2S,3S,4R,5S)--N-[3-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy-N-(oxan-4-- yl)hexanamide; (2S,3S,4R,5S)--N-[4-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-N-(3-methan- esulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-[4-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-N-[2-(2-hyd- roxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-[4-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-N-(4-hydrox- ybutyl) hexanamide; (2S,3S,4R,5S)--N-(4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-[2-(- 2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-N-(1,1-dioxo-1.lamda..- sup.6-thian-4-yl)-2,3,4,5,6-pentahydroxy-hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(oxan-4-ylmethyl) hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-[3-(2-oxopyrrolidin-1-yl) propyl]hexanamide; (2S,3S,4R,5S)--N-(2-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}ethyl)-2,3,4,5,6-pentahydroxy-N-meth- ylhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-N-(1,1-dioxo-1.lamda..sup.6-- thian-4-yl)-2,3,4,5,6-pentahydroxy-hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-N-[2-(1,1-dioxo-1.lamda- ..sup.6,4-thiomorpholin-4-yl)ethyl]-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(3-- methanesulfonylpropyl) hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(2-m- ethanesulfonylethyl)hexanamide; (2S,3S,4R,5S)--N-[4-({(3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]-4-methylphenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-N-(oxan-4-y- l)hexanamide; (2S,3S,4R,5S)--N-(4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(3-m- ethanesulfonylpropyl)hexanamide; (2S,3S,4R,5S)--N-(4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(oxa- n-4-yl)hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-N-(2-acetamidoethyl)-2,- 3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-N-(2-acetamidoethyl)-2,3,4,5,- 6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(ox- an-4-yl)hexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-N-(3-acetamidopropyl)-2,3,4,5- ,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-N-(4-acetamidobutyl)-2,- 3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-N-(4-acetamidobutyl)-2,3,4,5,- 6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-N-(1,1-dioxo-1.lamda..sup.6-t- hian-4-yl)-2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(4-m- ethanesulfonamidobutyl) hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(2-methanesulfonamidoethyl) hexanamide; ethyl N-{2-[(2S,3S,4R,5S)--N-[4-({(4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyr- idin-3-yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentah- ydroxyhexanamido]ethyl)}carbamate; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-N-(3-acetamidopropyl)-2- ,3,4,5,6-pentahydroxy-hexanamide; ethyl N-{3-[(2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyri- din-3-yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahy- droxyhexanamido]propyl)}carbamate; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(2-m- ethanesulfonamidoethyl) hexanamide; ethyl N-{2-[(2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxyh- exanamido]ethyl)}carbamate; (2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxy-N-(3-m- ethanesulfonamidopropyl) hexanamide; ethyl N-{3-[(2S,3S,4R,5S)--N-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)-2,3,4,5,6-pentahydroxyh- exanamido]propyl)}carbamate; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-N-(4-acetamidobutyl)-2,3,4,5- ,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(4-- methanesulfonamidobutyl) hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-N-(1,1-dioxo-1.lamda..s- up.6-thian-4-yl)-2,3,4,5,6-pentahydroxy-hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(4-methanesulfonamidobutyl) hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(2-methanesulfonylethyl) hexanamide; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(2-methanesulfonylethyl) hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(2-methanesulfonamidoethyl) hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-N-(2-acetamidoethyl)-2- ,3,4,5,6-pentahydroxy-hexanamide; ethyl N-{2-[(2S,3S,4R,5S)--N-[3-({(4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyr- idin-3-yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-penta- hydroxyhexanamido]ethyl)}carbamate; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(3-methanesulfonamido-propyl)hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-N-(3-acetamidopropyl)-- 2,3,4,5,6-pentahydroxy-hexanamide; ethyl N-{3-[(2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyri- din-3-yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentah- ydroxyhexanamido]propyl)}carbamate; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-(3-methanesulfonamidopropyl) hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(3-- methanesulfonamidopropyl) hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy-N-(2-- methanesulfonamidoethyl) hexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-N-(3-acetamidopropyl)-2,3,4,- 5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-N-(2-acetamidoethyl)-2,3,4,5- ,6-pentahydroxyhexanamide; ethyl N-{3-[(2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy- hexanamido]propyl)}carbamate; ethyl N-{2-[(2S,3S,4R,5S)--N-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyrid- in-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}propyl)-2,3,4,5,6-pentahydroxy- hexanamido]ethyl}carbamate; (2S,3S,4R,5S)--N-[5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)pentyl]-2,3,4,5,6-pentahydroxy- -N-[2-(2-hydroxyethoxy)ethyl]hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-2,3,4,5,6-pentahydroxy- -N-(4-methanesulfonamidobutyl) hexanamide; (2S,3S,4R,5S)--N-[5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)pentyl]-2,3,4,5,6-pentahydroxy- -N-(4-hydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-[5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)pentyl]-2,3,4,5,6-pentahydroxy- -N-(5-hydroxypentyl) hexanamide; (2S,3S,4R,5S)--N-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)propyl]-N-(4-acetamidobutyl)-2- ,3,4,5,6-pentahydroxy-hexanamide; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(2-- methanesulfonylethyl) hexanamide; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-N-[2-(ethanesulfonyl)ethyl]-- 2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(4-- hydroxybutyl)hexanamide; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-2,3,4,5,6-pentahydroxy-N-(5-- hydroxypentyl)hexanamide; (2S,3S,4R,5S)--N-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl- ]cyclopropoxy}methyl)benzenesulfinyl]pentyl}-2,3,4,5,6-pentahydroxyhexanam- ide; (2S,3S,4R,5S)--N-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)benzenesulfonyl]pentyl}-2,3,4,5,6-pentahydroxyhex- anamide; (2S,3S,4R,5S)--N-(carbamoylmethyl)-N-(5-{[4-chloro-3-({1-[4-(2-cy- clopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-- 2,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(carbamoylmethyl)-N-[5-({(4-chloro-3-[({1-[4-(2-cyclopro- poxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)pentyl]-2- ,3,4,5,6-pentahydroxyhexanamide; (2S,3S,4R,5S)--N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-y- l]cyclopropoxy}methyl)phenyl]sulfanyl}pentyl)-2,3,4,5,6-pentahydroxyhexana- mide; (2R,3R,4R,5S)-6-[(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridi- n-3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}butyl)(2-methanesulfonylethyl)a- mino]hexane-1,2,3,4,5-pentol; (2R,3R,4R,5S)-6-[(3-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}propyl)(2-methanesulfonylethyl)amino- ]hexane-1,2,3,4,5-pentol; (2R,3R,4R,5S)-6-[(4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl)-4-methylphenyl]sulfanyl}butyl)(2-methanesulfonylethyl)amino]- hexane-1,2,3,4,5-pentol; 3-(1-{[2-chloro-5-(methylsulfanyl)phenyl]methoxy}cyclopropyl)-4-(2-cyclop- ropoxyphenyl) pyridine; 1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]-N-{([5-methyl-2-(methylsulfanyl)- pyridin-4-yl]methyl}cyclopropan-1-amine; 4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-(p- ropan-2-yl) phenyl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]bu- tanamide; 1-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cycl- opropoxy}methyl)phenyl]sulfanyl}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]urea; 1-[3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}sulfanyl)propyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]urea; 1-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}- amino)methyl]phenyl}sulfanyl)butyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydrox- yhexyl]urea; (2S,3S,4R,5S)--N-[4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-- yl]cyclopropyl}amino)methyl]phenyl}sulfanyl)butyl]-2,3,4,5,6-pentahydroxy-- N-[2-(2-oxoimidazolidin-1-yl)ethyl]hexanamide; 1-(3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl) phenyl]sulfanyl}propyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl]urea; 1-{2-[2-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]c- yclopropyl}amino)methyl]phenyl}sulfanyl)ethoxy]ethyl}-3-[(2S,3R,4R,5R)-2,3- ,4,5,6-pentahydroxyhexyl]urea; 1-(4-{[(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]sulfanyl}pentyl)carbamoyl]amino}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]urea; 1-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}butyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan- -2-yl]urea; 1-(4-{[(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]sulfanyl}butyl)carbamoyl]amino}butyl)-3-[(2S,3R,4R,5R)-2,3,4,5,6-p- entahydroxyhexyl]urea; 1-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}pentyl)-3-[(1r,4r)-4-({[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]carbamoyl}amino) cyclohexyl]urea; 2-(4-{[(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]sulfanyl}pentyl)carbamoyl]amino}piperidin-1-yl)-N-[(2S,3R,4R,5R)-2- ,3,4,5,6-pentahydroxyhexyl]acetamide; 1-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}butyl)-3-[(1r,4r)-4-({[(2S,3R,4R,5R)-2,3,4,5,6-pent- ahydroxyhexyl]carbamoyl}amino) cyclohexyl] urea; 2-(4-{[(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- poxy}methyl) phenyl]sulfanyl}butyl)carbamoyl]amino}piperidin-1-yl)-N-[(2S,3R,4R,5R)-2,- 3,4,5,6-pentahydroxyhexyl]acetamide; 1-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}pentyl)-3-[(1 s,4s)-4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl}amino) cyclohexyl]urea; 1-(4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}butyl)-3-[(1 s,4s)-4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl}amino) cyclohexyl]urea; 1-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}pentyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexa- n-2-yl]urea; 1-[2-(2-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl)phenyl]sulfanyl}ethoxy)ethyl]-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahy- droxyhexan-2-yl]urea; 1-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfinyl]pentyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]urea; 1-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) benzenesulfonyl]pentyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea- ; 1-(2-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropo- xy}methyl) benzenesulfonyl]ethoxy}ethyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentah- ydroxyhexan-2-yl]urea; 1-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfinyl]pentyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexa- n-2-yl]urea; 1-{5-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}m- ethyl) benzenesulfonyl]pentyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexa- n-2-yl]urea; 1-(2-{2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl) benzenesulfinyl]ethoxy}ethyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahy- droxyhexan-2-yl]urea; 5-({6-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl- ]-5-methylpyridin-2-yl}sulfanyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl]pentanamide; 4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]benzenesulfonyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]butanamide; 4-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amin- o)methyl]benzenesulfinyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]butanamide; 4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}ami- no)methyl]phenyl)}sulfanyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]b- utanamide; 4-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino)methyl]phenyl)}sulfanyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-- pentahydroxyhexyl]butanamide; 4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-me- thylphenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]butanami- de; 4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4- -methylphenyl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl]butanamide; 4-({6-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl- ]-5-methylpyridin-2-yl}sulfanyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl]butanamide; 4-({6-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl- ]-5-methylpyridin-2-yl}sulfanyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]butanamide; 4-({4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl- ]-5-methylpyrimidin-2-yl}sulfanyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]butanamide; 4-({4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}amino)methyl- ]-5-methyl-pyrimidin-2-yl}sulfanyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]butanamide; 5-{[6-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-5-me- thylpyridin-2-yl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pe- ntanamide; 5-{[6-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}me- thyl)-5-methylpyridin-2-yl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-p- entahydroxyhexyl]pentanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-ethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(2-hydroxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(3-hydroxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentah- ydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(dimethylamino)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]butanamide; N-(carbamoylmethyl)-4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3- -yl]cyclopropoxy}methyl)phenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentah- ydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(2-methoxyethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(2-methanesulfonylethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6- -pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-propy- lbutanamide; N-benzyl-4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) phenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-N-(prop- an-2-yl)butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(oxan-4-yl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy- hexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[(methylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(dimethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4- ,5,6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(ethylcarbamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5,- 6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(3-methoxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentah- ydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[(dimethylcarbamoyl)methyl]-N-[(2S,3R,4R,5R)-2,3,4,- 5,6-pentahydroxyhexyl]butanamide; N-(2-carbamoylethyl)-4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-- 3-yl]cyclopropoxy}methyl)phenyl]sulfanyl}-N-[(2S,3R,4R,5R)-2,3,4,5,6-penta- hydroxyhexyl]butanamide; 3-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}ami- no)methyl]phenyl)}sulfanyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]propanamide; 3-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]propanamide; 5-({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}ami- no)methyl]phenyl)}sulfanyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydro- xyhexyl]pentanamide; 2-[1-({[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy- }methyl)phenyl]sulfanyl) methyl)cyclopropyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]acetamide; 4-[({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}am- ino)methyl]phenyl)}sulfanyl)methyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pe- ntahydroxyhexyl]benzamide; 2-{1-[({4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}sulfanyl)methyl]cyclopropyl}-N-methyl-N-[(2S,3R,4R,5R- )-2,3,4,5,6-pentahydroxyhexyl]acetamide; 5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]pentanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(2-hydroxyethoxy)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(5-hydroxypentyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentah- ydroxyhexyl]butanamide; 4-({[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}me- thyl)phenyl]sulfanyl) methyl)-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]benzamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(morpholine-4-sulfonyl)ethyl]-N-[(2S,3R,4R,5R)-2- ,3,4,5,6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(3-hydroxy-2,2-dimethylpropyl)-N-[(2R,3S,4S,5S)-2,3- ,4,5,6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[(2R,3S,4S,5S)-2,3,4,5,6-pentahydroxyhexyl]-N-[(1s,- 4s)-4-hydroxycyclohexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N,2-dimethyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyh- exyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-2-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl- ]butanamide; 4-{[3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)-4-et- hylphenyl]sulfanyl}-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]- butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-(4-hydroxybutyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahy- droxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(dimethylsulfamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4- ,5,6-pentahydroxyhexyl]butanamide; 4-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}met- hyl)phenyl]sulfanyl}-N-[2-(methylsulfamoyl)ethyl]-N-[(2S,3R,4R,5R)-2,3,4,5- ,6-pentahydroxyhexyl]butanamide; N-(5-{[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]sulfanyl}pentyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexy- l]acetamide; 1-(4-{N-ethyl-4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclo- propyl}amino) methyl]benzenesulfonamido}butyl)-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyh- exan-2-yl]urea; 2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl}ami- no)methyl]phenol; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -N,N-diethylbenzene-1-sulfonamide; 2-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl) benzenesulfonamido]ethane-1-sulfonic acid; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- benzene-1-sulfonamide; 1-{2-[2-({4-chloro-3-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cyclop- ropoxy)methyl]phenyl}sulfanyl)ethoxy]ethyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pen- tahydroxyhexan-2-yl]urea; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -N-methyl-N-(propan-2-yl)benzene-1-sulfonamide; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -N-(propan-2-yl)benzene-1-sulfonamide; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -N-methyl-N-propylbenzene-1-sulfonamide; 4-chloro-N-cyclopentyl-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropoxy}methyl)-N-methylbenzene-1-sulfonamide; 4-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}meth- yl) benzenesulfonyl]-3,3-dimethylmorpholine; 3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl]-1-{4-[N-(propan-2-yl)4- -chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)be- nzenesulfonamido]butyl}urea; (2S,3S,4R,5S)-2,3,4,5,6-pentahydroxy-N-{4-[N-(propan-2-yl)4-chloro-3-({1-- [4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)benzenesulfonami- do]butyl}hexanamide; N-tert-butyl-4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopr- opoxy}methyl) benzene-1-sulfonamide; 4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}methyl)- -N-(oxan-4-yl)benzene-1-sulfonamide; (2S)--S-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl)phenyl]-1-hydroxypropane-2-sulfonamido; (2R)--S-[4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropox- y}methyl)phenyl]-1-hydroxypropane-2-sulfonamido; 2-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)-N-(2,5-dichlorobenzyl)propan-2-a- mine; 4-(4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy- )methyl)phenethyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)benzamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N,N-dimethylbenzamide; 1-(5-(4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)m- ethyl)phenoxy)pentyl)-3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea; 3-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)benzyl)oxy)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)benzamide; 4-chloro-5-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -2-fluoro-N-isopropyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)u- reido)butyl) benzenesulfonamide; N-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)phenyl) sulfonylacetamide; 4-chloro-5-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -2-methoxy-N,N-dimethylbenzenesulfonamide; 4-chloro-5-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -2-hydroxy-N,N-dimethylbenzenesulfonamide; 1-(4-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)- methyl)phenyl)sulfonyl)-1,4-diazepan-1-yl)ethan-1-one; 6-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)phenyl)sulfonyl)-2-methoxy-5,6,7,8-tetrahydro-1,6-naphthyridine; 6-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)phenyl)sulfonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-ol; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-methyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)ureido)b- utyl-1,1,2,2,3,3,4,4-d8)benzenesulfonamide; (2R,3S,4R,5S)-5-(3-(4-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3- -yl)cyclopropoxy)methyl)-N-methylphenyl)sulfonamido)butyl)ureido)hexane-1,- 2,3,4,6-pentayl pentapropionate; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-(methylthio)phenyl)pyridi- ne; 4-(2-cyclopropoxyphenyl)-3-(2-((2,5-dichlorobenzyl)oxy)propan-2-yl)pyr- idine; 4-(2-cyclopropoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclobutyl)p- yridine; 4-(2-cyclopropoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopenty- l)pyridine; 4-(2-cyclopropoxyphenyl)-3-(3-((2,5-dichlorobenzyl)oxy)tetrahydrofuran-3-- yl)pyridine; 4-chloro-3-(((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropyl)amino)m- ethyl)-N-isopropyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl- )ureido)butyl)benzenesulfonamide; 4-(2-cyclopropoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)ethyl)pyridine; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclobutoxy)methyl)-- N-isopropyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)ureido- )butyl)benzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclobutoxy)methyl)-- N-isopropyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)ureido)buty- l)benzenesulfonamide; 5-(4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)meth- yl)phenethyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)picolinamide; 4-chloro-3-(((3-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)tetrahydrofuran-3-y- l)oxy)methyl)-N-isopropyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhex- an-2-yl)ureido)butyl) benzenesulfonamide; 4-chloro-3-(((3-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)tetrahydrofuran-3-y- l)oxy)methyl)-N-isopropyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhex- yl)ureido)butyl) benzenesulfonamide; 4-chloro-3-(((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropyl)amino)m- ethyl)-N-isopropyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urei- do)butyl)benzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)ethoxy)methyl)-N-iso- propyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)ureido)buty- l)benzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)ethoxy)methyl)-N-iso- propyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)ureido)butyl)ben- zenesulfonamide; 4-chloro-3-(((2-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)propan-2-yl)amino)m- ethyl)-N-isopropyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl- )ureido)butyl)benzenesulfonamide; 1-(4-(4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)m- ethyl)phenoxy)butyl)-3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea; 3-((4-chloro-3-((1-(4-(2-cyclopropoxyl)enyl)pyridin-3-yl)cyclopropoxy)met- hyl)benzyl)oxy)-N-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)benzamid- e; 6-((4-chloro-3-((1-(4-(2-cyclopropoxyl)enyl)pyridin-3-yl)cyclopropoxy)m- ethyl)benzyl)oxy)-N-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)nicoti- namide; 2-((4-chloro-3-((1-(4-(2-cyclopropoxyl)enyl)pyridin-3-yl)cycloprop- oxy)methyl)benzyl)thio)-1-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl)-1H-imidazole-5-carboxamide; 2-((4-chloro-3-((1-(4-(2-cyclopropoxyl)enyl)pyridin-3-yl)cyclopropoxy)met- hyl)benzyl)thio)-1-methyl-N-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-y- l)-1H-imidazole-5-carboxamide; 1-(5-(4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)m- ethyl)phenoxy)pentyl)-3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)ur- ea; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)meth- yl)-N-isobutyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)ure- ido)butyl)benzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-isobutyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)ureido)buty- l)benzenesulfonamide; 4-chloro-5-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -2-fluoro-N-isopropyl-N-(4-(3-((2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2- -yl)ureido)butyl) benzenesulfonamide; 4-chloro-5-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -2-fluoro-N-isopropyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)u- reido)butyl) benzenesulfonamide; 4-(2-chloro-6-methoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)py- ridine; N-(4-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclop- ropoxy)methyl)-N-methylphenyl)sulfonamido)butyl)acetamide; 4-(2-chlorophenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)pyridine; 1-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)phenyl)sulfonyl)-4-methyl-1,4-diazepane; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-(thiazol-2-yl)benzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-phenylbenzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-(2,2,2-trifluoroethyl)benzenesulfonamide; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(o-tolyl)pyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-methoxy-4-methylphenyl)py- ridine; 3-(1-((2-chloro-5-(N-(4-((2S,3S,4R,5S)-2,3,4,5,6-pentahydroxyhexan- amido)butyl)sulfamoyl)benzyl)oxy)cyclopropyl)-4-(2-cyclopropoxyphenyl)pyri dine 1-oxide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-methyl-N-(4-(3-((2S,3R,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl)ureido)b- utyl)benzenesulfonamide; (1S,4S)-2-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopro- poxy)methyl)phenyl)sulfonyl)-5-methyl-2,5-diazabicyclo[2.2.1]heptane; 4-(2-cyclopropoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)propyl)pyridine; 1-((1S,4S)-5-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclo- propoxy)methyl)phenyl)sulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethan-1- -one; 4-(2-cyclopropoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)p- yridazine; 1-(4-(2-cyclopropoxyphenyl)pyridazin-3-yl)-N-(2,5-dichlorobenzy- l)cyclopropan-1-amine; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)-6-ethylpyridin-3-yl)cyclopropoxy- )methyl)-N-methyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)ureid- o)butyl)benzenesulfonamide; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)-6-ethylpyridin-3-yl)cyclopropoxy- )methyl)-N-methyl-N-(4-(3-methyl-3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhe- xyl)ureido)butyl) benzenesulfonamide; 4-(2-cyclopropoxyphenyl)-5-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-2-eth- ylpyridine; 1-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-5H-chromeno[3,4-c]pyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-5-ethoxy-4-phenylpyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-5-methoxy-4-phenylpyridine; 1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)-N-(2,5-dichlorophenyl)cyclopropa- ne-1-carboxamide; 4-(2-cyclopropoxyphenyl)-3-(1-((2,5-dichlorophenoxy)methyl)cyclopropyl)py- ridine; 6-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cycloprop- oxy)methyl)phenoxy) methyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)nicotinamide; 4-(2-cyclopropoxyphenyl)-3-(1-(((2,5-dichlorobenzyl)oxy)methyl)cyclopropy- l)pyridine; 6-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)benzyl)oxy)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)nicotinamide; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-methoxy-6-methylphenyl)py- ridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-methoxy-3-methylph- enyl)pyridine; 4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N-methyl-N-(4-(3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)ureido)butyl)- benzamide; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-methoxy-5-(trif- luoromethoxy)phenyl)pyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-methoxy-5-(trifluoromethy- l)phenyl)pyridine; 4-(3-chloro-2-methoxyphenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)py- ridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-phenylpyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-methoxy-5-methylphenyl)py- ridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2,2-difluorobenzo[d]- [1,3]dioxol-4-yl)pyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(3-methoxyphenyl)pyridine; 4-(3-chlorophenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)pyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(4-methoxyphenyl)pyridine; 3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)-4-(2-(methylsulfonyl)phenyl)py- ridine; and 4-(4-chlorophenyl)-3-(1-((2,5-dichlorobenzyl)oxy)cyclopropyl)pyridine. 12. A prodrug of a compound of Formula (f) having a Formula (IF) or Formula (II): ##STR00878## wherein: P is a cleavable group selected from --O, --CH.sub.2OC(O)(C.sub.1-C.sub.6) alkyl, or --CH.sub.2OC(O)NR.sub.s (C.sub.1-C.sub.6) alkyl, wherein the alkyl is optionally substituted with --OC(O)(C.sub.1-C.sub.3) alkyl; and R.sub.s is H or (C.sub.1-C.sub.6) alkyl; Q is C.dbd.(O), --CH.sub.2--, --NR.sub.5-- or --O--; when Q is C.dbd.(O) then Q.sub.1 is --NR.sub.5--, when Q is --NR.sub.5-- or --O-- then Q.sub.1 is --CH.sub.2--, or when Q is --CH.sub.2-- then Q.sub.1 is --O(CH.sub.2).sub.0-1-- or --NR.sub.5--; X.sub.1 is CR.sub.6 or N; X.sub.2 is CR.sub.7 or N; X.sub.3 is CR.sub.8 or N; X.sub.4 is CR.sub.9 or N; Y is CR.sub.b or N; R.sub.a and R.sub.b are each independently H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, or halogen; R.sub.1 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, halogen, --S(O).sub.p(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, or --O-heterocycloalkyl, wherein the alkyl, alkoxy, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, (C.sub.1-C.sub.4) alkoxy, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.4) alkyl, and --N((C.sub.1-C.sub.4) alkyl).sub.2; or R.sub.1 and R.sub.a together with the carbon atoms to which they are attached form a heterocycloalkyl; or R.sub.1 and R.sub.3, when on adjacent atoms, together with the carbon atoms to which they are attached form a heterocycloalkyl optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, and halogen; R.sub.2 is independently (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, or (C.sub.1-C.sub.6) haloalkoxy; R.sub.2' is independently H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, or (C.sub.1-C.sub.6) haloalkoxy; or R.sub.2 and R.sub.2' together with the carbon atom to which they are attached form a (C.sub.3-C.sub.8) cycloalkyl or heterocycloalkyl; each R.sub.3 is independently, at each occurrence, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, halogen, --S(O).sub.p(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, or --O-heterocycloalkyl, wherein the alkyl, alkoxy, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, (C.sub.1-C.sub.4) alkoxy, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.4) alkyl, and --N((C.sub.1-C.sub.4) alkyl).sub.2; or R.sub.1 and R.sub.3 together with the carbon atoms to which they are attached form a heterocycloalkyl optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, and halogen; R.sub.4 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --OH, --NH.sub.2, CN, --S(O).sub.m(C.sub.1-C.sub.6) alkyl, --NH(C.sub.1-C.sub.4) alkyl, or --N((C.sub.1-C.sub.4) alkyl).sub.2; R.sub.5 is H, (C.sub.1-C.sub.6) alkyl, --C(O)NR.sub.10R.sub.11, --C(O)(C.sub.1-C.sub.6) alkyl, or --C(O)O(C.sub.1-C.sub.6) alkyl; each R.sub.6 and R.sub.9 is independently H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --OH, --NH.sub.2, CN, --S(O).sub.o(C.sub.1-C.sub.6) alkyl, --NH(C.sub.1-C.sub.4) alkyl, or --N((C.sub.1-C.sub.4) alkyl).sub.2; each R.sub.7 and R.sub.8 is independently H, (C.sub.1-C.sub.8) alkenyl, (C.sub.1-C.sub.8) alkynyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, halogen, (C.sub.3-C.sub.8) cycloalkyl, (C.sub.3-C.sub.8) cycloalkenyl, heterocycloalkyl, --OH, --NH.sub.2, --S(O).sub.qNH.sub.2, --S(O).sub.qOH, CN, or (C.sub.1-C.sub.18) alkyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.18) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.q--, --C(O)--, --C(CH.sub.2)--, or --C(NH)--, provided that when any two methylene in the alkyl is replaced, then two --O--, two --S(O).sub.q--, or two --NR.sub.13-- and --O-- and --NR.sub.13-- are not contiguous, wherein the alkyl is optionally substituted with one or more R.sub.12, and wherein the cycloalkyl and cycloalkenyl are optionally substituted with one or more R.sub.13; R.sub.10 and R.sub.11 are each independently H or (C.sub.1-C.sub.6) alkyl optionally substituted with one or more substituent independently selected from the group consisting of --NH.sub.2 and OH; R.sub.12 is D, --OH, halogen, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, --C(O)OH, --OC(O)(C.sub.1-C.sub.6) alkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl, heteroaryl, or R.sub.17, wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, halogen, and R.sub.14; R.sub.13 is H, --OH, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl, heteroaryl, or (C.sub.1-C.sub.12) alkyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.12) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl is replaced, then O and N are not contiguous and wherein the alkyl is optionally substituted with one or more R.sub.15, and wherein the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of --OH, --C(O)OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, and --N((C.sub.1-C.sub.6) alkyl).sub.2; R.sub.14 is (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, --O-heterocycloalkyl, (C.sub.1-C.sub.12) alkyl or (C.sub.2-C.sub.12) alkenyl, wherein 0 to 7 methylene of the (C.sub.1-C.sub.12) alkyl and the (C.sub.2-C.sub.12) alkenyl are optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl and alkenyl are optionally substituted with one or more R.sub.15, and the cycloalkyl and heterocycloalkyl are optionally substituted with one or more R.sub.16; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form C.dbd.(O); or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atoms to which they are attached form a (C.sub.3-C.sub.8) cycloalkyl or heterocycloalkyl optionally substituted with one or more R.sub.13; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form a (C.sub.3-C.sub.8) spirocycloalkyl or a spiroheterocycloalkyl optionally substituted with one or more R.sub.13; or when R.sub.12 is cycloalkyl or heterocycloalkyl, two R.sub.14 together with the atom to which they are attached form a (C.sub.6-C.sub.10) aryl or heteroaryl optionally substituted with one or more R.sub.13; R.sub.15 is --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, (C.sub.6-C.sub.10) aryl or heteroaryl, wherein the (C.sub.3-C.sub.8) cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, --C(O)OH, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and oxo; R.sub.16 is --OH, --C(O)OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, (C1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.3-C.sub.8) cycloalkyl, heterocycloalkyl, --O--(C.sub.3-C.sub.8) cycloalkyl, --O-heterocycloalkyl, (C.sub.6-C.sub.10) aryl or heteroaryl, wherein the (C.sub.3-C.sub.8) cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents selected from the group consisting of (C.sub.1-C.sub.6) hydroxyalkyl, (C.sub.1-C.sub.6) aminoalkyl, --C(O)OH, --OH, --NH.sub.2, --NH(C.sub.1-C.sub.6) alkyl, --N((C.sub.1-C.sub.6) alkyl).sub.2, and oxo; R.sub.17 is (C.sub.1-C.sub.18) alkyl or (C.sub.2-C.sub.18) alkenyl, wherein 0 to 8 methylene of the (C.sub.1-C.sub.18) alkyl and the (C.sub.2-C.sub.18) alkenyl are optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl and alkenyl are optionally substituted with one or more R.sub.18; R.sub.18 is R.sub.19, (C.sub.6-C.sub.10) aryl, or heteroaryl optionally substituted with one or more R.sub.21; R.sub.19 is (C.sub.1-C.sub.18) alkyl wherein 0 to 8 methylene of the (C.sub.1-C.sub.18) alkyl is optionally replaced by a moiety selected from the group consisting of --O--, --NR.sub.13--, --S(O).sub.r--, --C(O)--, or --C(NH)--, provided that a when any two methylene in the alkyl or alkenyl is replaced, then O and N are not contiguous and wherein the alkyl is optionally substituted with one or more R.sub.20; R.sub.20 is (C.sub.6-C.sub.10) aryl or heteroaryl optionally substituted with one or more R.sub.21; R.sub.21 is H, (C.sub.1-C.sub.6) alkyl, (C.sub.1-C.sub.6) alkoxy, (C.sub.1-C.sub.6) haloalkyl, (C.sub.1-C.sub.6) haloalkoxy, or halogen; or two R.sub.21 together when on adjacent atoms form a cycloalkyl or heterocycloalkyl optionally substituted with one or more R.sub.22; R.sub.22 is --C(O)NH.sub.2, --C(O)NH(C.sub.1-C.sub.6) alkyl, --C(O)N((C.sub.1-C.sub.6) alkyl).sub.2, --C(O) (C.sub.3-C.sub.7) cycloalkyl, or --C(O)heterocycloalkyl, wherein the cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of --OH and CN; each m, o, p, q, and r is independently, at each occurrence, 0, 1, or 2; and n is 0, 1, or 2. 13. The prodrug of claim 12, wherein P is --O, --CH.sub.2OC(O)C(CH.sub.3).sub.3, or --CH.sub.2OC(O)N(CH.sub.3)CH.sub.2CH.sub.2OC(O)CH.sub.3. 14. The compound of claim 12, selected from the group consisting of: 3-{1-[(2-chloro-5-{methyl[4-({[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-- 2-yl]carbamoyl}amino)butyl]sulfamoyl}phenyl)methoxy]cyclopropyl}-4-(2-cycl- opropoxyphenyl)pyridin-1-ium-1-olate; 3-[1-({2-chloro-5-[(2S)-6-({[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-- yl]carbamoyl}amino)hexan-2-yl]phenyl}methoxy)cyclopropyl]-4-(2-cyclopropox- yphenyl)pyridin-1-ium-1-olate; 3-{1-[(2-chloro-5-{ethyl[4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]c- arbamoyl}amino) butyl]sulfamoyl}phenyl)methoxy]cyclopropyl}-4-(2-cyclopropoxyphenyl)pyrid- in-1-ium-1-olate; 3-{1-[(2-chloro-5-{ethyl[4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]c- arbamoyl)}amino) butyl]sulfamoyl}phenyl)methoxy]cyclopropyl}-4-(2-cyclopropoxyphenyl)-1-{[- (2,2-dimethylpropanoyl)oxy]methyl}pyridin-1-ium; 1-[({[2-(acetyloxy)ethyl](methyl)carbamoyl}oxy)methyl]-3-{1-[(2-chloro-5-- {ethyl[4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl}amino)buty- l]sulfamoyl}phenyl)methoxy]cyclopropyl}-4-(2-cyclopropoxyphenyl)pyridin-1-- ium; 3-(1-{[2-chloro-5-(ethylsulfamoyl)phenyl]methoxy}cyclopropyl)-4-(2-cy- clopropoxyphenyl) pyridin-1-ium-1-olate; 3-(1-{[2-chloro-5-(methylsulfamoyl)phenyl]methoxy}cyclopropyl)-4-(2-cyclo- propoxyphenyl) pyridin-1-ium-1-olate; 3-{1-[(2-chloro-5-sulfamoylphenyl)methoxy]cyclopropyl}-4-(2-cyclopropoxyp- henyl)pyridin-1-ium-1-olate; 3-{1-[(2-chloro-5-{[4-({[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbam- oyl}amino)butyl](propan-2-yl)sulfamoyl}phenyl)methoxy]cyclopropyl}-4-(2-cy- clopropoxyphenyl)pyridin-1-ium-1-olate; and 3-(1-((2-chloro-5-(N-(4-((2S,3S,4R,5S)-2,3,4,5,6-pentahydroxyhexanamido)b- utyl)sulfamoyl) benzyl)oxy)cyclopropyl)-4-(2-cyclopropoxyphenyl)pyridine 1-oxide. 15. A pharmaceutical composition comprising, a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 16. The pharmaceutical composition of claim 15, wherein the composition further comprises one or more additional biologically active agents. 17. The pharmaceutical composition of claim 16, wherein the one or more additional biologically active agents prolong the TGR5-mediated GLP-1 signal. 18. The pharmaceutical composition of claim 16, wherein the one or more additional biologically active agents is a DPP-4 inhibitor selected from the group consisting of sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin, gemigliptin, omarigliptin, and dutogliptin. 19. A method for treating postprandial hyperphosphatemia or proteinuria in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 20. A method of treating chronic kidney disease (CKD) or end-stage renal disease (ESRD) comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 21. A method for reducing serum creatinine levels, reducing FGF23 levels, reducing the hyperphosphatemic effect of active vitamin D, reducing serum parathyroid hormone (PTH), reducing urinary phosphorous, reducing renal hypertrophy, reducing intima-localized vascular calcification, or reducing heart hypertrophy in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 22. A method for delaying time to renal replacement therapy (RRT) in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 23. A method for attenuating hyperparathyroidism in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the hyperparathyroidism is secondary hyperparathyroidism. 24. A method for improving endothelial dysfunction in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the endothelial dysfunction is induced by postprandial serum phosphorus. 25. A method for normalizing serum phosphorus levels in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 26. A method for reducing phosphate burden in an elderly patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 27. A method for decreasing dietary phosphate uptake in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 28. A method for treating and/or preventing a side effect of chemotherapy or radiation treatment in a patient in need thereof, comprising, administering to a patient in need thereof an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the side effect of chemotherapy is diarrhea, abdominal cramping, vomiting, or structural and functional damage of the intestinal epithelium resulting from chemotherapy treatment. 29. The method of claim 28, wherein the diarrhea is induced by an immune checkpoint inhibitor. 30. The compound of claim 1, wherein the compound is 1-{2-[2-({4-chloro-3-[(1-{4-[2-(oxetan-3-yloxy)phenyl]pyridin-3-yl}cyclop- ropoxy)methyl]phenyl}sulfanyl)ethoxy]ethyl}-3-[(2S,3R,4R,5R)-2,3,4,5,6-pen- tahydroxyhexyl]urea. 31. The compound of claim 1, wherein the compound is 4-[(4-{2,5-dichloro-4-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopro- pyl}amino)methyl]phenyl}butyl)[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]c- arbamoyl]butanoic acid. 32. The compound of claim 1, wherein the compound is 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-1-{4-[(2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexyl]piperazin-1- -yl}pentan-1-one. 33. The compound of claim 1, wherein the compound is 5-[2,5-dichloro-4-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropoxy}- methyl)phenyl]-N-(2,3-dihydroxypropyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahyd- roxyhexyl]pentanamide. 34. The compound of claim 1, wherein the compound is N-({5-[(2S)-6-aminohexan-2-yl]-2-chlorophenyl}methyl)-1-[4-(2-cyclopropox- yphenyl)pyridin-3-yl]cyclopropan-1-amine. 35. The compound of claim 1, wherein the compound is (5S)-5-{4-chloro-3-[({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclopropyl- }amino)methyl]phenyl}hexanoic acid. 36. The compound of claim 1, wherein the compound is 1-{4-[N-methyl4-chloro-3-({1-[4-(2-cyclopropoxyphenyl)pyridin-3-yl]cyclop- ropoxy}methyl)benzenesulfonamido]butyl}-3-[(2S,3R,4S,5R)-1,3,4,5,6-pentahy- droxyhexan-2-yl]urea. 37. The compound of claim 1, wherein the compound is 4-(4-Chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)meth- yl)phenethyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)benzamide. 38. The compound of claim 1, wherein the compound is 4-Chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)methyl)- -N,N-dimethylbenzamide. 39. The compound of claim 1, wherein the compound is 6-((4-chloro-3-((1-(4-(2-cyclopropoxyphenyl)pyridin-3-yl)cyclopropoxy)met- hyl)phenyl)sulfonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-ol.

Details for Patent 10,392,413

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2035-12-18