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Last Updated: April 25, 2024

Claims for Patent: 10,350,283

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Summary for Patent: 10,350,283

Title:	Method for preventing or treating M tuberculosis infection
Abstract:	The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
Inventor(s):	Marchand; Martine (Rixensart, BE)
Assignee:	GLAXOSMITHKLINE BIOLOGICALS, S.A. (BE)
Application Number:	16/135,553
Patent Claims:	1. A polynucleotide comprising a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO: 4. 2. The polynucleotide according to claim 1, comprising the nucleic acid sequence of SEQ ID NO: 3. 3. A pharmaceutical composition comprising the polynucleotide according to claim 2, wherein the polynucleotide is provided in a viral vector. 4. A pharmaceutical composition, comprising the polynucleotide according to claim 2 wherein the polynucleotide is provided in a bacterium host cell. 5. The pharmaceutical composition according to claim 4, wherein the bacterium host cell is Bacillus Calmette-Guerin.

Details for Patent 10,350,283

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989	⤷ Try a Trial	2040-01-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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