Last Updated: June 8, 2026

Claims for Patent: 10,301,391

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Summary for Patent: 10,301,391

Title:	BCMA and CD3 bispecific T cell engaging antibody constructs
Abstract:	The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
Inventor(s):	Tobias Raum, Markus Münz, Johannes Brozy, Peter Kufer, Patrick Hoffmann, Matthias Friedrich, Benno Rattel, Pamela BOGNER, Andreas Wolf, Cornelius Pompe
Assignee:	Boehringer Ingelheim International GmbH , Amgen Research Munich GmbH , Amgen Inc
Application Number:	US15/422,619

Details for Patent 10,301,391

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	July 13, 2017	⤷ Start Trial	2037-02-02
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	January 29, 2019	⤷ Start Trial	2037-02-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,301,391

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Country	Patent Number	Estimated Expiration
Argentina	107521	⤷ Start Trial
Australia	2017216230	⤷ Start Trial
Australia	2023237216	⤷ Start Trial
Brazil	112018015715	⤷ Start Trial
Canada	3010704	⤷ Start Trial
Chile	2018002057	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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