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Last Updated: April 19, 2024

Claims for Patent: 10,287,353

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Summary for Patent: 10,287,353

Title:	Combination therapies of HDAC inhibitors and PD-1 inhibitors
Abstract:	Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.
Inventor(s):	Bissonnette; Reid P. (Carlsbad, CA), Rolland; Alain (San Diego, CA), Gillings; Mireille (Las Vegas, NV)
Assignee:	HUYA Bioscience International, LLC (San Diego, CA)
Application Number:	16/103,865
Patent Claims:	1. A method for treating melanoma in a subject, comprising administering to said subject a therapeutically effective amount of a compound of the following formula: ##STR00006## in combination with nivolumab, wherein the subject has been treated with a PD-L1 checkpoint inhibitor. 2. The method of claim 1, wherein the compound is administered at an amount of about 30 mg BIW. 3. The method of claim 1, wherein nivolumab is administered as an intravenous infusion over about 30 minutes. 4. The method of claim 1, wherein the melanoma is Stage II, III or IV melanoma. 5. The method of claim 1, wherein the melanoma is resistant/refractory melanoma. 6. The method of claim 1, wherein the melanoma is metastatic.

Details for Patent 10,287,353

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	12/22/2014	⤷ Try a Trial	2036-05-11
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	10/04/2017	⤷ Try a Trial	2036-05-11
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	08/27/2021	⤷ Try a Trial	2036-05-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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