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Last Updated: March 7, 2021

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Claims for Patent: 10,150,800

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Summary for Patent: 10,150,800
Title:EGFR-binding modular recognition domains
Abstract: EGFR-binding modular recognition domains (MRDs) and complexes containing such MRDs linked to antibodies are described. The use of such MRDs and complexes are also described.
Inventor(s): Roschke; Viktor (Bethesda, MD), Lafleur; David (Washington, DC), Hilbert; David M. (Bethesda, MD), Kiener; Peter (Potomac, MD)
Assignee: Zyngenia, Inc. (Washington, DC)
Application Number:14/776,816
Patent Claims:1. A modular recognition domain (MRD) capable of binding an epidermal growth factor receptor (EGFR), wherein the MRD comprises the amino acid sequence YAEHCRQFPSDWICTLLP (SEQ ID NO: 3109).

2. A complex comprising the MRD of claim 1, wherein the MRD is fused to a heterologous protein.

3. The complex of claim 2, wherein the heterologous protein is an antibody.

4. The complex of claim 3, wherein the MRD and the antibody bind different targets.

5. The complex of claim 3, wherein the MRD and the antibody are operably linked by a linker.

6. The complex of claim 5, wherein the antibody binds EGFR.

7. The complex of claim 6, which further comprises an additional covalently bound MRD, wherein the additional covalently bound MRD binds Erb-B2 Receptor Tyrosine Kinase 3 (ErbB3) and comprises an amino acid sequence selected from the group consisting of SEQ ID NO:3499-4094.

8. A pharmaceutical composition comprising the complex of claim 6.

9. The complex of claim 6, wherein the antibody is cetuximab.

10. The complex of claim 9, which further comprises an additional covalently bound MRD, wherein the additional covalently bound MRD binds ErbB3 and comprises an amino acid sequence selected from the group consisting of SEQ ID NO:3499-4094.

11. A pharmaceutical composition comprising the complex of claim 9.

12. A complex comprising an antibody and an MRD, wherein the antibody is cetuximab and the MRD comprises the amino acid sequence YAEHCRQFPSDWICTLLP (SEQ ID NO: 3109).

13. A pharmaceutical composition comprising the complex of claim 12.

Summary for Patent:   Start Trial

PCT Information
PCT FiledMarch 14, 2014PCT Application Number:PCT/US2014/029077
PCT Publication Date:September 18, 2014PCT Publication Number:WO2014/144600

Details for Patent 10,150,800

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Zyngenia, Inc. (Washington, DC) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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