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Last Updated: April 25, 2024

Claims for Patent: 10,123,876

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Summary for Patent: 10,123,876

Title:	Cohesive bone composition
Abstract:	A cohesive bone composition is made from a moldable bone composition intermixed with a bone gel composition. The cohesive bone composition is made from human cadaver bone. A fluid can be added, the fluid may also be laden with cells.
Inventor(s):	Namin; Shabnam (Miami, FL), Weston; Wendy W. (Miami, FL), Maldonado; Edgar S. (Miami, FL), Gonzales; Silvia Daniela (Miam, FL)
Assignee:	Vivex Biomedical, Inc. (Atlanta, GA)
Application Number:	15/647,995
Patent Claims:	1. A method of manufacturing a cohesive bone composition of a mixture of a moldable bone composition and a bone gel composition comprises the steps of: wherein the method of manufacturing a moldable bone composition comprises the steps of: cutting cortical bone plates into long pieces; shaving the cortical bone plates to form cortical strands or shavings 3 mm or greater in length; demineralizing a first portion of the cortical shavings; grinding another portion of the cortical shavings; resulting in cortical bone having three portions, a demineralized cortical shavings portion, a mineralized cortical shavings portion and a powered cortical portion; cutting and grinding cancellous bone to form a portion of mineralized crushed cancellous bone from a size of 1000 to 1700 microns; freeze-drying each portion; mixing together all of the portions in a predetermined ratio to form a freeze-dried composition; and wherein the method of making a bone gel composition consisting of cortical bone comprises the steps of: preparing cortical bone by cutting the cortical bone into pieces, freeze-drying the pieces and then grinding into particles and demineralizing the ground particles and the freeze-drying the demineralized ground particles to form DBM particles; autoclaving a volume of the DBM particles mixed with sterile water in a 2:1 ratio by volume for a predetermined time at a pre-set temperature and pressure to form a gelatin; cooling the gelatin to form a bone gel composition; packaging the resulting bone gel composition; and wherein a volume of moldable bone composition is mixed with a volume of the bone gel composition and wetted with a fluid to form the cohesive bone composition. 2. The method of manufacturing a cohesive bone composition of claim 1 further comprises the step of adding a vial of fluid to the packages. 3. The method of manufacturing a cohesive bone composition of claim 2 wherein the vial of fluid can be sterile water, lactated Ringer's solution, normal saline, plasma, blood or any other commonly used material with or without cells added.

Details for Patent 10,123,876

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2036-04-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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