Claims for Patent: 10,099,430

Summary for Patent: 10,099,430

Title:	Three-dimensional printing process for producing a self-destructible temporary structure
Abstract:	A three dimensional printing method for producing a self-destructible temporary structure, comprising: depositing, layer by layer, a degradable material solution having a biosynthetic copolymer as a degradable component and a disintegrating agent solution comprising enzyme as the disintegrating agent, wherein the disintegrating agent is capable of disintegrating the degradable component. The steps include curing deposited layers to form gel layers and activating the disintegrating agent by an external trigger during or after depositing the disintegrating agent to gradually degrade the degradable component.
Inventor(s):	Dikovsky; Daniel (Rehovot, IL), Napadensky; Eduardo (Netanya, IL)
Assignee:	STRATASYS LTD (Rehovot, IL)
Application Number:	15/390,572
Patent Claims:	1. A three dimensional printing method for easy removal of a support construction, comprising: depositing a modeling material to form a three-dimensional object, said modeling material comprising a disintegrating agent; depositing a support material to provide a support construction adjacent to the three-dimensional object, said support material comprising a degradable component degradable by the disintegrating agent; hardening said modeling material and said support material, wherein after hardening the disintegrating agent is released into the support material at the interface between the modeling and support materials, enabling easy removal of the support construction from the three dimensional object. 2. The method of claim 1, wherein depositing is being done by one or more inkjet printing heads. 3. The method of claim 1, wherein the disintegrating agent is an enzyme, catalyst, acid or base. 4. The method of claim 3, wherein the enzyme is esterase, trypsin, collagenase, cellulose or dextranase. 5. The method of claim 1, wherein the degradable component is a photopolymer, wax or a combination thereof. 6. The method of claim 1, wherein the degradable component is a polymer. 7. The method of claim 6, wherein said polymer is a copolymer, a block-copolymer, a photopolymer, a polysaccharide, reactive polymer-protein hybrid molecules, a biosynthetic hydrogel material or a wax. 8. The method of claim 7, wherein said copolymer comprises polyethyleneglycol (PEG) or poly(acrylic acid) or poly(hyaluronic acid) or polycaprolactone or poly(vinyl alcohol). 9. The method of claim 1, wherein the disintegrating agent decomposes at least one chemical bond or at least one physical bond within the degradable component. 10. The method of claim 1 comprising: activating the disintegrating agent by an external trigger during or after depositing to degrade the degradable component. 11. The method of claim 10, wherein the external trigger is at least one of heat, microwave irradiation, light irradiation or ultrasound. 12. The method of claim 1, wherein the disintegrating agent is encapsulated in smart carrier nanoparticles and the disintegrating agent is released by an external trigger. 13. The method of claim 1, wherein the disintegrating agent is contained in porous nanoparticles and the disintegrating agent is released by an external trigger. 14. The method of claim 1, wherein the disintegrating agent degrades the degradable component within 1 hour to 72 hours. 15. The method of claim 1, wherein hardening is being done does UV curing, phase change, drying or crystallization.

Details for Patent 10,099,430

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2029-06-01