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Last Updated: June 19, 2024

CLINICAL TRIALS PROFILE FOR RAMUCIRUMAB


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Biosimilar Clinical Trials for ramucirumab

This table shows clinical trials for biosimilars. See the next table for all clinical trials
Trial ID Title Status Sponsor Phase Start Date Summary
NCT03766607 ↗ Trastuzumab Beyond Progression in HER2 Positive Metastatic Gastric Cancer Withdrawn Korean South West Oncology Group Phase 2 2019-09-30 The aim of this study is to evaluate the efficacy and safety of combination therapy with ramucirumab, paclitaxel, and trastuzumab biosimilar as second line treatment of HER2 positive metastatic gastric cancer after failure of first line chemotherapy including trastuzumab. This study is a phase II, single-arm, open label, multi-center study.
NCT05800418 ↗ Clinical Study to Compare the Pharmacokinetics and Safety of Ramucirumab Injection With Cyramza ® in Healthy Male Volunteers Completed Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Phase 1 2019-11-04 Ramucirumab is a biosimilar drug of CYRAMZA® produced by Chiatai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., LTD. It is a vascular endothelial growth factor receptor 2 (VEGFR-2) antagonist. This single-center, randomized, double-blind, single-dose, parallel phase I study of Ramucirumab injection versus Cyramza ® in healthy male volunteers was designed to evaluate the similarities in pharmacokinetics, tolerance, safety and immunogenicity of Ramucirumab and CYRAMZA®.
>Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for ramucirumab

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00533702 ↗ A Study of IMC-1121B (Ramucirumab) With or Without Dacarbazine in Metastatic Malignant Melanoma Completed Eli Lilly and Company Phase 2 2007-11-01 The primary objective of this study is to determine the progression-free survival (PFS) of participants with previously untreated metastatic malignant melanoma when treated with IMC-1121B (ramucirumab) alone or in combination with dacarbazine.
NCT00683475 ↗ A Study of IMC-A12 or Ramucirumab Plus Mitoxantrone and Prednisone in Prostate Cancer Completed Eli Lilly and Company Phase 2 2008-08-01 The purpose of this study is to determine whether IMC-A12 or IMC-1121B (ramucirumab) with Mitoxantrone and Prednisone is effective in the treatment of metastatic androgen- independent prostate cancer (APIC).
NCT00703326 ↗ Phase III Study of Docetaxel + Ramucirumab or Placebo in Breast Cancer Completed Eli Lilly and Company Phase 3 2008-08-06 The objective of this study is to compare the progression-free survival (PFS) of the drug combination ramucirumab plus docetaxel to placebo plus docetaxel in previously untreated participants with human epidermal growth factor receptor 2 (HER2)-negative, unresectable, locally-recurrent or metastatic breast cancer.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for ramucirumab

Condition Name

Condition Name for ramucirumab
Intervention Trials
Gastric Cancer 20
Gastric Adenocarcinoma 16
Gastroesophageal Junction Adenocarcinoma 16
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Condition MeSH

Condition MeSH for ramucirumab
Intervention Trials
Adenocarcinoma 42
Stomach Neoplasms 31
Carcinoma, Non-Small-Cell Lung 30
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Clinical Trial Locations for ramucirumab

Trials by Country

Trials by Country for ramucirumab
Location Trials
United States 803
Japan 42
China 41
United Kingdom 40
Spain 39
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Trials by US State

Trials by US State for ramucirumab
Location Trials
Texas 41
California 40
New York 39
Florida 35
Pennsylvania 33
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Clinical Trial Progress for ramucirumab

Clinical Trial Phase

Clinical Trial Phase for ramucirumab
Clinical Trial Phase Trials
Phase 3 16
Phase 2/Phase 3 6
Phase 2 69
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Clinical Trial Status

Clinical Trial Status for ramucirumab
Clinical Trial Phase Trials
Completed 45
Recruiting 40
Active, not recruiting 24
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Clinical Trial Sponsors for ramucirumab

Sponsor Name

Sponsor Name for ramucirumab
Sponsor Trials
Eli Lilly and Company 70
National Cancer Institute (NCI) 13
Southwest Oncology Group 7
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Sponsor Type

Sponsor Type for ramucirumab
Sponsor Trials
Industry 121
Other 74
NIH 13
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