Multicenter Investigation of Limitation of Infarct Size (MILIS)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1977-09-01
To assess the ability of two separate therapeutic interventions, propranolol and
hyaluronidase, to limit the ultimate size of an acute myocardial infarction. A secondary
objective was to assess the influence of these therapies upon ventricular function and
morbidity following myocardial infarction.
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
Completed
Bausch & Lomb Incorporated
Phase 1
2004-03-01
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity
to Vitrase following a single intradermal injection of 3 USP units Vitrase. Less than or
equal to 10% hypersensitivity response was considered acceptable.
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
Completed
Bausch & Lomb Incorporated
Phase 1
2004-07-01
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity
to Vitrase following a single intradermal injection of 3 USP units Vitrase. Less than or
equal to a 10% hypersensitivity response was considered acceptable.
Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment
Completed
Bausch & Lomb Incorporated
Phase 2
2005-07-01
The purpose of this study is to assess the efficacy of intravitreous injections of Vitrase to
induce posterior vitreous detachment(PVD) in subjects with moderate to severe
non-proliferative diabetic retinopathy.
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