Biological Predictive Factors of Response to ESA in Low Risk MDS Patients
Association pour la recherche sur les Affections Malignes en Immunologie Sanguine
In this trial, the investigators would like to understand why a small percentage of patients
will be refractory to ESA (independently of International prognostic scoring system (IPSS)
and % of blasts). In a retrospective study of the "Groupe Francophone des Myélodysplasies
(GFM)" , the investigators showed that about 43% of patients are refractory or will relapse
after initial response to ESA and it has been shown that these patients have a poorer
survival. The investigators plan to give a 12-week treatment of Epoetin alfa or zeta in low
risk MDS patients and measure different biological factors to predict response to ESA:
- evaluation by flow cytometry before and after treatment of the degree of
dyserythropoiesis and dysgranulopoiesis which could explain the primary resistance or
loss of response of a subset of patients,
- screening by molecular biology of predictive factors of response to ESA,
- Iron homeostasis will be measured via hepcidin, GDF-15 and ferritin levels.
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