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Last Updated: March 28, 2024

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NUPLAZID Drug Patent Profile


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Which patents cover Nuplazid, and what generic alternatives are available?

Nuplazid is a drug marketed by Acadia Pharms Inc and is included in two NDAs. There are fourteen patents protecting this drug and two Paragraph IV challenges.

This drug has eighty-eight patent family members in twenty-two countries.

The generic ingredient in NUPLAZID is pimavanserin tartrate. There are two drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the pimavanserin tartrate profile page.

DrugPatentWatch® Generic Entry Outlook for Nuplazid

Nuplazid was eligible for patent challenges on April 29, 2020.

There have been nine patent litigation cases involving the patents protecting this drug, indicating strong interest in generic launch. Recent data indicate that 63% of patent challenges are decided in favor of the generic patent challenger and that 54% of successful patent challengers promptly launch generic drugs.

Indicators of Generic Entry

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Drug patent expirations by year for NUPLAZID
Drug Prices for NUPLAZID

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Recent Clinical Trials for NUPLAZID

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SponsorPhase
ACADIA Pharmaceuticals Inc.Phase 2
Ohio State UniversityPhase 2
ACADIA Pharmaceuticals Inc.Early Phase 1

See all NUPLAZID clinical trials

Pharmacology for NUPLAZID
Anatomical Therapeutic Chemical (ATC) Classes for NUPLAZID
Paragraph IV (Patent) Challenges for NUPLAZID
Tradename Dosage Ingredient Strength NDA ANDAs Submitted Submissiondate
NUPLAZID Tablets pimavanserin tartrate 10 mg 207318 1 2020-04-29
NUPLAZID Capsules pimavanserin tartrate 34 mg 210793 5 2020-04-29

US Patents and Regulatory Information for NUPLAZID

NUPLAZID is protected by fourteen US patents.

Patents protecting NUPLAZID

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS

Formulations of pimavanserin
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial

Combination of pimavanserin and cytochrome P450 modulators
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS

Formulations of pimavanserin
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial

Formulations of pimavanserin
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS

Combination of pimavanserin and cytochrome P450 modulators
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS


Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF PARKINSON'S DISEASE PSYCHOSIS

N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phe- nylmethyl)carbamide and its tartrate salt and crystalline forms
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial

Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF PSYCHOSIS OR A SYMPTOM THEREOF

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF A NEURODEGENERATIVE DISEASE OR A SYMPTOM THEREOF

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Patent Number: ⤷  Try a Trial
Patent Expiration: ⤷  Try a Trial
Patented Use: TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Acadia Pharms Inc NUPLAZID pimavanserin tartrate TABLET;ORAL 207318-001 Apr 29, 2016 DISCN Yes No ⤷  Try a Trial ⤷  Try a Trial Y Y ⤷  Try a Trial
Acadia Pharms Inc NUPLAZID pimavanserin tartrate TABLET;ORAL 207318-001 Apr 29, 2016 DISCN Yes No ⤷  Try a Trial ⤷  Try a Trial Y Y ⤷  Try a Trial
Acadia Pharms Inc NUPLAZID pimavanserin tartrate CAPSULE;ORAL 210793-001 Jun 28, 2018 AB RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial ⤷  Try a Trial
Acadia Pharms Inc NUPLAZID pimavanserin tartrate TABLET;ORAL 207318-002 Jun 28, 2018 AB RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial ⤷  Try a Trial
Acadia Pharms Inc NUPLAZID pimavanserin tartrate TABLET;ORAL 207318-001 Apr 29, 2016 DISCN Yes No ⤷  Try a Trial ⤷  Try a Trial ⤷  Try a Trial
Acadia Pharms Inc NUPLAZID pimavanserin tartrate CAPSULE;ORAL 210793-001 Jun 28, 2018 AB RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial Y ⤷  Try a Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for NUPLAZID

International Patents for NUPLAZID

See the table below for patents covering NUPLAZID around the world.

Country Patent Number Title Estimated Expiration
South Korea 101095939 ⤷  Try a Trial
Japan 4664564 ⤷  Try a Trial
Hong Kong 1126776 SELECTIVE SEROTONIN 2A/2C RECEPTOR INVERSE AGONISTS AS THERAPEUTICS FOR NEURODEGENERATIVE DISEASES ⤷  Try a Trial
Hong Kong 1051684 ⤷  Try a Trial
Canada 2692001 SYNTHESE DE N-(4-FLUOROBENZYL)-N-(1-METHYLPYPERIDINE-4-YL)-N'-(4-2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE ET SON SEL DE TARTRATE ET DES FORMES CRISTALLINES (SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS) ⤷  Try a Trial
Japan 2010174026 SELECTIVE SEROTONIN 2A/2C RECEPTOR INVERSE AGONIST AS THERAPEUTIC FOR NEURODEGENERATIVE DISEASE ⤷  Try a Trial
>Country >Patent Number >Title >Estimated Expiration

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.