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Profile for Tradename: MUSE

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Muse is a drug marketed by Meda Pharms and is included in one NDA. It is available from one supplier. There is one patent protecting this drug.

This drug has twenty-three patent family members in sixteen countries.

The generic ingredient in MUSE is alprostadil. There are seven drug master file entries for this compound. Four suppliers are listed for this compound. Additional details are available on the alprostadil profile page.

Summary for Tradename: MUSE

Patents:1
Applicants:1
NDAs:1
Suppliers / Packagers: see list4

Clinical Trials for: MUSE

The Use of Prostaglandin E1 in Head and Neck Microsurgery
Status: Recruiting Condition: Microsurgery; Head and Neck; Prostaglandin E1; Thrombosis; Complications

Protective Effect of Lipo-PGE1 on Myocardial Injury Following Percutaneous Coronary Intervention
Status: Not yet recruiting Condition: Prostaglandin E1; Percutaneous Coronary Intervention

Prostaglandin E1 in Outpatients With Intermittent Claudication
Status: Completed Condition: Stage II Peripheral Arterial Occlusive Disease; Intermittent Claudication Fontaine Stage II PAOD

Alprostadil in Maculopathy Study (AIMS)
Status: Terminated Condition: Macular Degeneration

Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
Status: Completed Condition: Peripheral Arterial Occlusive Disease

Sildenafil Citrate and Alprostadil in Treating Patients Undergoing Bilateral Nerve-Sparing Robotic-Assisted Prostatectomy for Nonmetastatic Prostate Cancer
Status: Completed Condition: Prostate Cancer; Male Erectile Disorder; Stage I Prostate Cancer; Stage II Prostate Cancer

Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
Status: Withdrawn Condition: Infant, Newborn; Respiratory Insufficiency; Pulmonary Hypertension; Respiratory Distress Syndrome, Newborn; Streptococcal Infections

Medigus Ultrasonic Surgical Endostapler (MUSE) Registry
Status: Recruiting Condition: Gastroesophageal Reflux Disease (GERD)

Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy
Status: Active, not recruiting Condition: Kidney Diseases; Diabetes Mellitus; Acute Kidney Injury; Kidney Failure, Chronic; Renal Insufficiency

Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)
Status: Terminated Condition: Prematurity; Respiratory Insufficiency; Pulmonary Hypertension; Respiratory Distress Syndrome, Newborn

Courtesy of ClinicalTrials.org
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Meda Pharms
MUSE
alprostadil
SUPPOSITORY;URETHRAL020700-001Nov 19, 1996RXNo5,886,039<disabled>Y<disabled>
Meda Pharms
MUSE
alprostadil
SUPPOSITORY;URETHRAL020700-004Nov 19, 1996RXYes5,886,039<disabled>Y<disabled>
Meda Pharms
MUSE
alprostadil
SUPPOSITORY;URETHRAL020700-002Nov 19, 1996RXNo5,886,039<disabled>Y<disabled>
Meda Pharms
MUSE
alprostadil
SUPPOSITORY;URETHRAL020700-003Nov 19, 1996RXNo5,886,039<disabled>Y<disabled>
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Non-Orange Book Patents for Tradename: MUSE

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
5,843,961 Method and composition for treating erectile dysfunction<disabled in preview>
5,942,512 Method and composition for treating erectile dysfunction<disabled in preview>
5,849,803 Method of treating erectile dysfunction with nitroglycerine<disabled in preview>
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International Patent Family for Tradename: MUSE

Country Document Number Publication Date
Norway910828Apr 30, 1991
European Patent Office0357581Sep 16, 1998
Norway301046Sep 08, 1997
Sweden463851Feb 04, 1991
Canada1335346Apr 25, 1995
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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