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Profile for Tradename: EMEND

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Emend is a drug marketed by Merck and Merck And Co Inc and is included in two NDAs. It is available from three suppliers. There are five patents protecting this drug and three Paragraph IV challenges.

This drug has two hundred and nine patent family members in fifty-two countries.

The generic ingredient in EMEND is fosaprepitant dimeglumine. There are five drug master file entries for this compound. One supplier is listed for this compound. There is one tentative approval for this compound. Additional details are available on the fosaprepitant dimeglumine profile page.

Summary for Tradename: EMEND

Suppliers / Packagers: see list15

Clinical Trials for: EMEND

Re-examination Study of EMEND (Aprepitant) (MK-0869-184)
Status: Completed Condition: Chemotherapy-induced Nausea and Vomiting

Efficacy of Aprepitant (Emend®) in Children
Status: Recruiting Condition: Nausea; Vomiting; Childhood Cancer

Study Assessing Fosaprepitant in Advanced NSCLC Patients Treated With Carboplatin Based Chemotherapy
Status: Not yet recruiting Condition: Non-small Cell Lung Cancer; Vomiting; Nausea; Emesis

Pharmacokinetic Characteristics and Anti-Inflammatory Effects of Aprepitant In HIV-Infected Subjects
Status: Recruiting Condition: HIV Infection

A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
Status: Terminated Condition: Chemotherapy-Induced Nausea and Vomiting

Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)
Status: Recruiting Condition: Chemotherapy-induced Nausea and Vomiting

Comparison of Adding EMEND to PONV/PDNV Treatment Regimen
Status: Not yet recruiting Condition: Postoperative Nausea and Vomiting

Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
Status: Completed Condition: Lymphoma

Emend and Ondansetron Compared to Ondansetron Alone to Prevent CINV in Glioma Patients Receiving Temozolomide
Status: Recruiting Condition: Nausea; Vomiting; Glioma

Fosaprepitant for Nausea and Vomiting During High-dose Interleukin-2 (HD IL-2) for Metastatic Melanoma and Renal Cell Carcinoma
Status: Recruiting Condition: Chemotherapy-induced Nausea and Vomiting

Courtesy of
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
CAPSULE;ORAL021549-003Jun 30, 2006RXNo5,719,147<disabled>YY <disabled>
Merck And Co Inc
fosaprepitant dimeglumine
POWDER;INTRAVENOUS022023-002Nov 12, 2010RXYes5,716,942<disabled> <disabled>
CAPSULE;ORAL021549-001Mar 26, 2003RXNo6,096,742<disabled>YY <disabled>
CAPSULE;ORAL021549-002Mar 26, 2003RXYes6,096,742<disabled>YY <disabled>
CAPSULE;ORAL021549-001Mar 26, 2003RXNo8,258,132<disabled>Y <disabled>
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Paragraph IV activity for: EMEND

Drugname Dosage Strength RLD Submissiondate
fosaprepitant dimeglumineInjection150 mg/vialEmend1/25/2012
fosaprepitant dimeglumineInjection115 mg/vialEmend1/25/2012
aprepitantCapsule40 mg, 80 mg and 125 mgEmend11/3/2008

International Patent Family for Tradename: EMEND

Country Document Number Publication Date
Spain2184794Apr 16, 2003
TaiwanI249403Feb 21, 2006
HungaryT76324Aug 28, 1997
Norway996549Dec 29, 1999
Hungary9403804Feb 28, 1995
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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