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Profile for Tradename: COMTAN

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Comtan is a drug marketed by Orion Pharma and is included in one NDA. It is available from ten suppliers. There is one patent protecting this drug and one Paragraph IV challenge.

This drug has forty-four patent family members in thirty-seven countries.

The generic ingredient in COMTAN is entacapone. There are nineteen drug master file entries for this compound. Ten suppliers are listed for this compound. Additional details are available on the entacapone profile page.

Summary for Tradename: COMTAN

Suppliers / Packagers: see list17

Pharmacology for Tradename: COMTAN

Clinical Trials for: COMTAN

Augmenting Effects of L-DOPS With Carbidopa and Entacapone
Status: Terminated Condition: Parkinson Disease; Multiple System Atrophy; Autonomic Nervous System Diseases

Effect of Entacapone on Bodyweight Loss in Obese Population
Status: Recruiting Condition: Obesity

Pilot Study of Entacapone for Methamphetamine Abuse
Status: Recruiting Condition: Methamphetamine Dependence

COMT Polymorphism and Entacapone Efficacy
Status: Completed Condition: Parkinson's Disease

Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients With "Wearing-off" Phenomenon
Status: Completed Condition: Parkinson's Disease

Carbidopa/Levodopa/Entacapone Versus Immediate Release (IR) Carbidopa/Levodopa on Non-motor Symptoms in Patients With Idiopathic Parkinson's Disease and Demonstrating Non-motor Symptoms of Wearing Off
Status: Terminated Condition: Parkinson's Disease

Efficacy of Levodopa/Carbidopa/Entacapone vs Levodopa/Carbidopa in Parkinson's Disease Patients With Early Wearing-off
Status: Completed Condition: Parkinson's Disease

Entacapone Augmentation for Schizophrenia
Status: Completed Condition: Schizophrenia

Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy
Status: Completed Condition: Parkinson's Disease

Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
Status: Completed Condition: Parkinson's Disease With End of Dose "Wearing Off"

Courtesy of
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Orion Pharma
TABLET;ORAL020796-001Oct 19, 1999RXYes6,599,530<disabled>Y <disabled>
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Paragraph IV activity for: COMTAN

Drugname Dosage Strength RLD Submissiondate
entacaponeTablets200 mgComtan4/11/2007

International Patent Family for Tradename: COMTAN

Country Document Number Publication Date
Indonesia29026Jul 26, 2001
Portugal1112065Apr 30, 2004
Norway331641Feb 13, 2012
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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