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Patent: 6,287,539

Summary for Patent: 6,287,539

Title: Methods of imaging using osmotically stabilized microbubble preparations
Abstract:A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.
Inventor(s): Schutt; Ernest G. (San Diego, CA), Anderson; Charles David (Lebanon, NJ), Evitts; David P. (La Jolla, CA)
Assignee: Alliance Pharmaceuticals Corp. (San Diego, CA)
Application Number:08/841,846
Patent Claim Types:
see list of patent claims
Use; Compound;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Imcor Pharms Co
IMAGENT
dimyristoyl lecithin; perflexane
INJECTABLE;INTRAVENOUS021191May 31, 2002DISCNNo6,287,539<disabled>
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Patent activity for: 6,287,539

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Patent Number:6,287,539 Application Number:08/841,846 Issue Date:Sep 11 2001 Expiration Date:Sep 11 2013

International Patent Family for Patent: 6,287,539

Country Document Number Publication Date
Austria281183Nov 15, 2004
Australia8933898Jan 14, 1999
Australia731099Mar 22, 2001
Australia731671Apr 05, 2001
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