|Title:||Use of alpha-1C specific compounds to treat benign prostatic hyperplasia|
|Abstract:||A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human .alpha..sub.1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human .alpha..sub.1A adrenergic receptor, a human .alpha..sub.1B adrenergic receptor, and a human histamine H.sub.1 receptor, and, binds to a human .alpha..sub.2 adrenergic receptor with a binding affinity which is greater than ten-fold lower than the binding affinity with which the compound binds to such .alpha..sub.1C adrenergic receptor. Compounds meeting these criteria are provided.|
|Inventor(s):||Gluchowski; Charles (Danville, CA), Forray; Carlos C. (Paramus, NJ), Chiu; George (Bridgewater, NJ), Branchek; Theresa A. (Teaneck, NJ), Wetzel; John M. (Elmwood Park, NJ), Hartig; Paul R. (Pennington, NJ)|
|Assignee:||Synaptic Pharmaceutical Corporation (Paramus, NJ)|
|Patent Claim Types:|
see list of patent claims
|PCT Filed||November 12, 1993||PCT Application Number:||PCT/US93/10950|
|PCT Publication Date:||May 26, 1994||PCT Publication Number:||WO94/10989|
|Country||Document Number||Publication Date|
|South Africa||9308510||Aug 02, 1994|
|South Africa||9502763||Jan 05, 1996|
|WIPO (PCT)||9410989||May 26, 1994|
|WIPO (PCT)||9507075||Mar 16, 1995|
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