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Patent: 6,015,819

Summary for Patent: 6,015,819

Title: Use of alpha-1C specific compounds to treat benign prostatic hyperplasia
Abstract:A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human .alpha..sub.1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human .alpha..sub.1A adrenergic receptor, a human .alpha..sub.1B adrenergic receptor, and a human histamine H.sub.1 receptor, and, binds to a human .alpha..sub.2 adrenergic receptor with a binding affinity which is greater than ten-fold lower than the binding affinity with which the compound binds to such .alpha..sub.1C adrenergic receptor. Compounds meeting these criteria are provided.
Inventor(s): Gluchowski; Charles (Danville, CA), Forray; Carlos C. (Paramus, NJ), Chiu; George (Bridgewater, NJ), Branchek; Theresa A. (Teaneck, NJ), Wetzel; John M. (Elmwood Park, NJ), Hartig; Paul R. (Pennington, NJ)
Assignee: Synaptic Pharmaceutical Corporation (Paramus, NJ)
Application Number:08/244,354
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 6,015,819

PCT Information
PCT FiledNovember 12, 1993PCT Application Number:PCT/US93/10950
PCT Publication Date:May 26, 1994PCT Publication Number: WO94/10989

International Patent Family for Patent: 6,015,819

Country Document Number Publication Date
Australia7684894Mar 27, 1995
Australia5602994Jun 08, 1994
Australia2240495Nov 10, 1995
Australia700304Dec 24, 1998
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