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Patent: 5,958,961

Summary for Patent: 5,958,961

Title: Pharmaceutical composition for angiotensin II-mediated diseases
Abstract:This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally esterified carboxyl group; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R.sup.2 ; and Y is a bond, --O--, --S(O)m- (wherein m is 0, 1 or 2) or --N(R.sup.4)-- (wherein R.sup.4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
Inventor(s): Inada; Yoshiyuki (Kawanishi, JP), Kubo; Keiji (Riverside, CA)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/883,040
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Arbor Pharms Ireland
EDARBI
azilsartan kamedoxomil
TABLET;ORAL200796Feb 25, 2011RXYes5,958,961<disabled>YTREATMENT OF HYPERTENSION
Arbor Pharms Ireland
EDARBI
azilsartan kamedoxomil
TABLET;ORAL200796Feb 25, 2011RXNo5,958,961<disabled>YTREATMENT OF HYPERTENSION
Astrazeneca
ATACAND HCT
candesartan cilexetil; hydrochlorothiazide
TABLET;ORAL021093May 16, 2008RXYes5,958,961<disabled>YTREATMENT OF HYPERTENSION
Astrazeneca
ATACAND HCT
candesartan cilexetil; hydrochlorothiazide
TABLET;ORAL021093Sep 5, 2000RXNo5,958,961<disabled>YTREATMENT OF HYPERTENSION
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Foreign Priority and PCT Information for Patent: 5,958,961

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan5-133524Jun 07, 1993

International Patent Family for Patent: 5,958,961

Country Document Number Publication Date
United States5721263Feb 24, 1998
United States6228874May 08, 2001
United States2001004640Jun 21, 2001
United States6348481Feb 19, 2002
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