|Abstract:||Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.|
|Inventor(s):||Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
|Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|South Africa||9308620||Aug 04, 1994|
|WIPO (PCT)||9411387||May 26, 1994|
|United States||5468860||Nov 21, 1995|
|United States||5652365||Jul 29, 1997|
|This preview shows a limited data set|
Complete access is available with a Subscription
Export unavailable in trial.
Subscribe for complete access.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided information. There is no warranty that the information contained herein is error free. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Copyright © 2002-2014 thinkBiotech LLC. ISSN: 2162-2639