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Patent: 5,814,335

Summary for Patent: 5,814,335

Title: Sphingosomes for enhanced drug delivery
Abstract:Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
Inventor(s): Webb; Murray S. (Vancouver, CA), Bally; Marcel B. (Bowen Island, CA), Mayer; Lawrence D. (N. Vancouver, CA), Miller; James J. (Vancouver, CA), Tardi; Paul G. (Richmond, CA)
Assignee: Inex Pharmaceuticals Corporation (CA)
Application Number:08/932,375
Patent Claim Types:
see list of patent claims
Compound; Dosage form; Process; Delivery; Formulation; Composition;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Talon Therap
MARQIBO KIT
vincristine sulfate
INJECTABLE, LIPOSOMAL;INTRAVENOUS202497Aug 9, 2012RXYes5,814,335<disabled>Y
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International Patent Family for Patent: 5,814,335

Country Document Number Publication Date
WIPO (PCT)9535094Dec 28, 1995
United States5543152Aug 06, 1996
United States5741516Apr 21, 1998
Portugal804159Feb 27, 2004
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