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Patent: 5,639,443

Summary for Patent: 5,639,443

Title: Stabilized microbubble compositions
Abstract:A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
Inventor(s): Schutt; Ernest G. (San Diego, CA), Evitts; David P. (La Jolla, CA), Kinner; Rene Alta (San Diego, CA), Anderson; Charles David (Lebanon, NJ), Weers; Jeffry G. (San Diego, CA)
Assignee: Alliance Pharmaceutical Corp. (San Diego, CA)
Application Number:08/405,447
Patent Claim Types:
see list of patent claims
Compound; Device;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Imcor Pharms Co
IMAGENT
dimyristoyl lecithin; perflexane
INJECTABLE;INTRAVENOUS021191May 31, 2002DISCNNo5,639,443<disabled>
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International Patent Family for Patent: 5,639,443

Country Document Number Publication Date
WIPO (PCT)9503835Feb 09, 1995
WIPO (PCT)9626746Sep 06, 1996
United States6258339Jul 10, 2001
United States6280704Aug 28, 2001
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