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Patent: 5,591,762

Summary for Patent: 5,591,762

Title: Benzimidazoles useful as angiotensin-11 antagonists
Abstract:Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl] methyl]-biphenyl-2-carboxylic acid.
Inventor(s): Hauel; Norbert (Schemmerhofen, DE), Narr, deceased; Berthold (late of Biberach, DE), Ries; Uwe (Biberch, DE), van Meel; Jacobus C. A. (Mittelbiberach, DE), Wienen; Wolfgang (Biberach/Rissegg, DE), Entzeroth; Michael (Warthausen, DE)
Assignee: Dr. Karl Thomae GmbH (Biberach an der Riss, DE)
Application Number:08/457,204
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Boehringer Ingelheim
MICARDIS
telmisartan
TABLET;ORAL020850Apr 4, 2000RXNo5,591,762<disabled>TREATMENT OF HYPERTENSION
Boehringer Ingelheim
MICARDIS
telmisartan
TABLET;ORAL020850Nov 10, 1998RXNo5,591,762<disabled>TREATMENT OF HYPERTENSION
Boehringer Ingelheim
MICARDIS
telmisartan
TABLET;ORAL020850Nov 10, 1998RXYes5,591,762<disabled>YYTREATMENT OF HYPERTENSION
Boehringer Ingelheim
MICARDIS HCT
hydrochlorothiazide; telmisartan
TABLET;ORAL021162Nov 17, 2000RXNo5,591,762<disabled>YYTREATMENT OF HYPERTENSION
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Foreign Priority and PCT Information for Patent: 5,591,762

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany41 03 492.9Feb 06, 1991
Germany41 17 121.7May 25, 1991
Germany41 37 812.1Nov 16, 1991
Germany42 01 554.5Jan 22, 1992

International Patent Family for Patent: 5,591,762

Country Document Number Publication Date
Austria166346Jun 15, 1998
Austria141270Aug 15, 1996
Australia4209493Jan 27, 1994
Australia675433Feb 06, 1997
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