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Patent: 5,585,089

Summary for Patent: 5,585,089

Title: Humanized immunoglobulins
Abstract:Novel methods for producing, and compositions of humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.
Inventor(s): Queen; Cary L. (Los Altos, CA), Selick; Harold E. (Belmont, CA)
Assignee: Protein Design Labs, Inc. (Mountain View, CA)
Application Number:08/477,728
Patent Claim Types:
see list of patent claims
Compound; Composition;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Wyeth Pharms Inc
MYLOTARG
gemtuzumab ozogamicin
INJECTABLE;INJECTION021174May 17, 2000DISCNNo5,585,089<disabled>
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International Patent Family for Patent: 5,585,089

Country Document Number Publication Date
Austria133452Feb 15, 1996
Austria183753Sep 15, 1999
Austria251639Oct 15, 2003
Australia5153290Aug 13, 1990
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