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Patent: 5,575,987

Summary for Patent: 5,575,987

Title: Method of producing sustained-release microcapsules
Abstract:A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.
Inventor(s): Kamei; Shigeru (Takarazuka, JP), Yamada; Minoru (Kawanishi, JP), Ogawa; Yasuaki (Ohyamazaki-cho, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/562,634
Patent Claim Types:
see list of patent claims
Dosage form;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020011Oct 22, 1990RXYes5,575,987<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION019732Jan 26, 1989RXYes5,575,987<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020708Mar 7, 1997RXYes5,575,987<disabled>
Abbvie Endocrine Inc
LUPRON DEPOT
leuprolide acetate
INJECTABLE;INJECTION020517Dec 22, 1995RXYes5,575,987<disabled>
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Foreign Priority and PCT Information for Patent: 5,575,987

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan4-234821Sep 02, 1992

International Patent Family for Patent: 5,575,987

Country Document Number Publication Date
Austria175345Jan 15, 1999
Canada2105374Mar 03, 1994
Germany69322917Feb 18, 1999
Denmark0586238Aug 30, 1999
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