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Patent: 5,480,656
Summary for Patent: 5,480,656
| Title: | Prolonged release microcapsules |
| Abstract: | This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, wherein the composition ratio of lactic acid/glycolic acid in the copolymer or homopolymer is 80/10 to 100/0, and then subjecting said water-in oil emulsion to microencapsulation. |
| Inventor(s): | Okada; Hiroaki (Suita, JP), Inoue; Yayoi (Kyoto, JP), Ogawa; Yasuaki (Otokuni, JP) |
| Assignee: | Takeda Chemical Industries, Ltd. (Osaka, JP) |
| Application Number: | 08/188,918 |
| Patent Claim Types: see list of patent claims | Compound; Dosage form; |
Glossary
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | Type | RLD | Patent No. | Product | Substance | Delist_Flag | Patent Expiration | Patented / Exclusive Use | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Abbott Endocrine | LUPRON DEPOT-PED | leuprolide acetate | INJECTABLE; INJECTION | 020263 | Aug 15, 2011 | RX | Yes | 5,480,656 | Y | <disabled> | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Abbott Endocrine | LUPRON DEPOT | leuprolide acetate | INJECTABLE; INJECTION | 020517 | May 30, 1997 | RX | Yes | 5,480,656 | <disabled> | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Abbott Endocrine | LUPRON DEPOT | leuprolide acetate | INJECTABLE; INJECTION | 020517 | Dec 22, 1995 | RX | Yes | 5,480,656 | <disabled> | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Abbott Endocrine | LUPRON DEPOT | leuprolide acetate | INJECTABLE; INJECTION | 020708 | Mar 7, 1997 | RX | Yes | 5,480,656 | <disabled> | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Foreign Priority and PCT Information for Patent: 5,480,656
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| Japan | 2-033133 | Feb 13, 1990 |
International Patent Family for Patent: 5,480,656
| Country | Document Number | Publication Date | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| United States | 5643607 | Jul 01, 1997 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| United States | 5814342 | Sep 29, 1998 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Russia | 2018306 | Aug 30, 1994 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Russia | 2098121 | Dec 10, 1997 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The preview shows a limited data set. Complete access is available with a Subscription | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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