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Patent: 5,474,978

Summary for Patent: 5,474,978

Title: Insulin analog formulations
Abstract:The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.
Inventor(s): Bakaysa; Diane L. (Indianapolis, IN), Brems; David N. (Indianapolis, IN), Frank; Bruce H. (Indianapolis, IN), Havel; Henry A. (Indianapolis, IN), Pekar; Allen H. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/260,634
Patent Claim Types:
see list of patent claims
Formulation; Composition; Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Lilly
HUMALOG PEN
insulin lispro recombinant
INJECTABLE;INJECTION020563Aug 6, 1998DISCNNo5,474,978<disabled>HUMALOG IS AN INSULIN ANALOG THAT IS INDICATED IN THE TREATMENT OF PATIENTS WITH DIABETES MELLITUS FOR THE CONTROL OF HYPERGLYCEMIA
Lilly
HUMALOG MIX 75/25 KWIKPEN
insulin lispro protamine recombinant; insulin lispro recombinant
INJECTABLE;INJECTION021017Sep 6, 2007RXYes5,474,978<disabled>YYTREATMENT OF DIABETES MELLITUS
Lilly
HUMALOG MIX 75/25
insulin lispro protamine recombinant; insulin lispro recombinant
INJECTABLE;INJECTION021017Dec 22, 1999RXYes5,474,978<disabled>YYTREATMENT OF DIABETES MELLITUS
Lilly
HUMALOG MIX 50/50 KWIKPEN
insulin lispro protamine recombinant; insulin lispro recombinant
INJECTABLE;INJECTION021018Sep 6, 2007RXYes5,474,978<disabled>YYTREATMENT OF DIABETES MELLITUS
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International Patent Family for Patent: 5,474,978

Country Document Number Publication Date
South Africa9504943Sep 14, 1997
Serbia and Montenegro39695Aug 22, 1997
Taiwan421596Feb 11, 2001
Slovenia9500200Feb 29, 1996
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