Details for Patent: 5,472,949
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Summary for Patent: 5,472,949
Title: | N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine compounds, compositions and methods of using same |
Abstract: | The invention relates to N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine derivatives which are useful as an agent for treating tumors, pharmaceutical compositions including the same, a method of treating tumors and a method of preparing N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine derivatives for treating tumors. Compounds of formula (I), ##STR1## wherein R.sup.1 is a saturated or unsaturated, straight or branched hydrocarbon radical wherein the number of carbon atoms in the longest straight chain of this hydrocarbon radical ranges from three to seven, or is a radical of the formula --(CH.sub.2)n--.sup.Y wherein Y is a cyclohexyl radical, a C.sub.1 -C.sub.4 alkoxy radical or a phenyl radical and wherein when Y is a cyclohexyl radical n is an integer from 0 to 4, and when Y is C.sub.1 -C.sub.4 alkoxy radical or a phenyl radical n is an integer from 2 to 4, and R.sup.2 is a hydrogen atom or a radical easily hydrolyzable under physiological conditions, or a hydrate or solvate thereof. Compounds of formula (I) are useful in the treatment of tumors. |
Inventor(s): | Arasaki; Motohiro (Kanagawa, JP), Ishitsuka; Hideo (Kanagawa, JP), Kuruma; Isami (Kanagawa, JP), Miwa; Masanori (Kanagawa, JP), Murasaki; Chikako (Kanagawa, JP), Shimma; Nobuo (Kanagawa, JP), Umeda; Isao (Kanagawa, JP) |
Assignee: | Hoffmann-La Roche Inc. (Nutley, NJ) |
Application Number: | 08/167,392 |
Patent Claim Types: see list of patent claims | Compound; Composition; Use; |
Drugs Protected by US Patent 5,472,949
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 5,472,949
Foriegn Application Priority Data | ||
Foreign Country | Foreign Patent Number | Foreign Patent Date |
92121538 | Dec 18, 1992 |
International Family Members for US Patent 5,472,949
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Austria | 137244 | ⤷ Try a Trial | |||
Australia | 5069093 | ⤷ Try a Trial | |||
Australia | 671491 | ⤷ Try a Trial | |||
Bulgaria | 61485 | ⤷ Try a Trial | |||
Bulgaria | 98304 | ⤷ Try a Trial | |||
Brazil | 9305089 | ⤷ Try a Trial | |||
Canada | 2103324 | ⤷ Try a Trial | |||
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