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Patent: 5,472,949

Summary for Patent: 5,472,949

Title: N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine compounds, compositions and methods of using same
Abstract:The invention relates to N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine derivatives which are useful as an agent for treating tumors, pharmaceutical compositions including the same, a method of treating tumors and a method of preparing N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine derivatives for treating tumors. Compounds of formula (I), ##STR1## wherein R.sup.1 is a saturated or unsaturated, straight or branched hydrocarbon radical wherein the number of carbon atoms in the longest straight chain of this hydrocarbon radical ranges from three to seven, or is a radical of the formula --(CH.sub.2)n--.sup.Y wherein Y is a cyclohexyl radical, a C.sub.1 -C.sub.4 alkoxy radical or a phenyl radical and wherein when Y is a cyclohexyl radical n is an integer from 0 to 4, and when Y is C.sub.1 -C.sub.4 alkoxy radical or a phenyl radical n is an integer from 2 to 4, and R.sup.2 is a hydrogen atom or a radical easily hydrolyzable under physiological conditions, or a hydrate or solvate thereof. Compounds of formula (I) are useful in the treatment of tumors.
Inventor(s): Arasaki; Motohiro (Kanagawa, JP), Ishitsuka; Hideo (Kanagawa, JP), Kuruma; Isami (Kanagawa, JP), Miwa; Masanori (Kanagawa, JP), Murasaki; Chikako (Kanagawa, JP), Shimma; Nobuo (Kanagawa, JP), Umeda; Isao (Kanagawa, JP)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:08/167,392
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Hoffmann La Roche
XELODA
capecitabine
TABLET;ORAL020896Apr 30, 1998RXNo5,472,949*PED<disabled>Y
Hoffmann La Roche
XELODA
capecitabine
TABLET;ORAL020896Apr 30, 1998RXYes5,472,949*PED<disabled>Y
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Foreign Priority and PCT Information for Patent: 5,472,949

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
92121538Dec 18, 1992

International Patent Family for Patent: 5,472,949

Country Document Number Publication Date
Austria137244May 15, 1996
Australia671491Aug 29, 1996
Australia5069093Jun 30, 1994
Bulgaria61485Sep 30, 1997
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