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Patent: 5,407,914

Summary for Patent: 5,407,914

Title: Pulmonary surfactant protein and related polypeptides
Abstract:The present invention discloses useful peptides and synthetic pulmonary surfactants, as well as methods of making and using same. In a preferred embodiment, a synthetic pulmonary surfactant comprises one or more pharmaceutically acceptable phospholipids admixed with a polypeptide comprising at least 10 amino acid residues and no more than about 60 amino acid residues, said polypeptide including a sequence having alternating hydrophobic and hydrophilic amino acid residue regions. In other embodiments, a surfactant peptide has an amino acid residue sequence selected from the group consisting of KLLLLKLLLLKLLLLKLLLLK, KLLLLLLLLKLLLLLLLLKLL, and KKLLLLLLLKKLLLLLLLKKL.
Inventor(s): Cochrane; Charles G. (La Jolla, CA), Revak; Susan D. (San Diego, CA)
Assignee: The Scripps Research Institute (La Jolla, CA)
Application Number:08/060,833
Patent Claim Types:
see list of patent claims
Compound; Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Discovery Labs
SURFAXIN
lucinactant
SUSPENSION;INTRATRACHEAL021746Mar 6, 2012RXYes5,407,914<disabled>YYPREVENTION OF RESPIRATORY DISTRESS (RDS) IN PREMATURE INFANTS
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International Patent Family for Patent: 5,407,914

Country Document Number Publication Date
Austria397012Jun 15, 2008
Austria223436Sep 15, 2002
Austria199730Mar 15, 2001
Austria196298Sep 15, 2000
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