|Title:||19-nor-vitamin D compounds for use in treating hyperparathyroidism|
|Abstract:||This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.|
|Inventor(s):||DeLuca; Hector F. (Deerfield, WI), Schnoes; Heinrich K. (Madison, WI), Perlman; Kato L. (Madison, WI), Sicinski; Rafal R. (Warsaw, PL), Prahl; Jean M. (Madison, WI)|
|Assignee:||Wisconsin Alumni Research Foundation (Madison, WI)|
|Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|South Africa||9007119||Oct 30, 1991|
|WIPO (PCT)||9010620||Sep 20, 1990|
|United States||5237110||Aug 17, 1993|
|United States||5321018||Jun 14, 1994|
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