Details for Patent: 5,886,184
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Summary for Patent: 5,886,184
| Title: | Finasteride processes |
| Abstract: | Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17 beta -carboalkoxy-4-aza-5 alpha -androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production. |
| Inventor(s): | Ulf H. Dolling, James A. McCauley, Richard J. Varsolona |
| Assignee: | Merck Sharp and Dohme LLC |
| Application Number: | US08/824,426 |
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Patent Claim Types: see list of patent claims | Compound; Process; |
Drugs Protected by US Patent 5,886,184
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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International Family Members for US Patent 5,886,184
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Austria | 164850 | ⤷ Start Trial | |||
| Austria | 177112 | ⤷ Start Trial | |||
| Australia | 5078793 | ⤷ Start Trial | |||
| Australia | 658774 | ⤷ Start Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
