Details for Patent: 7,135,465
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Summary for Patent: 7,135,465
| Title: | Sustained release beadlets containing stavudine |
| Abstract: | Extended dosage forms of stavudine are provided comprising beadlets formed by extrusion-spheronization and coated with a seal coating. The beadlets are also coated with a modified release coating such that a hard gelatin capsule containing such beadlets will provide blood levels of stavudine over approximately 24 hours. The beadlets are prepared from a dry blend of stavudine, a spheronizing agent, a suitable diluent and a stabilizing amount of magnesium stearate. The magnesium stearate, in contrast to other similar pharmaceutical adjuncts, has been found to stabilize stavudine against degradation due to hydrolysis in the presence of the limited amount of water necessary for the extrusion-spheronization process. Also included in the scope of the invention are hard gelatin capsules containing, in addition to the stavudine beadlets, similar beadlets containing other therapeutic agents utilized to treat retroviral infections. |
| Inventor(s): | Abramowitz; Robert (West Windsor, NJ), O'Donoghue; Denise M. (Hightstown, NJ), Jain; Nemichand B. (West Windsor, NJ) |
| Assignee: | Bristol-Myers Squibb Company (Princeton, NJ) |
| Application Number: | 09/821,103 |
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Patent Claim Types: see list of patent claims | Dosage form; Use; Process; |
Drugs Protected by US Patent 7,135,465
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 7,135,465
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Argentina | 027748 | ⤷ Try a Trial | |||
| Australia | 4959101 | ⤷ Try a Trial | |||
| Bulgaria | 107157 | ⤷ Try a Trial | |||
| Brazil | 0109602 | ⤷ Try a Trial | |||
| Canada | 2404687 | ⤷ Try a Trial | |||
| China | 1187052 | ⤷ Try a Trial | |||
| China | 1420774 | ⤷ Try a Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
