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Details for Patent: 6,746,691

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Summary for Patent: 6,746,691

Title: Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
Abstract:Intermediate release nicotinic acid formulations having unique biopharmaceutical characteristics, which are suitable for oral administration once per day as a single dose preferably administered during the evening or at night for treating hyperlipidemia without causing drug-induced hepatotoxicity to such a level that requires the therapy to be discontinued, are disclosed. The intermediate nicotinic acid formulations can be administered as tablets in dosage strengths of, for example, 375 mg, 500 mg, 750 mg and 1000 mg. The 375 mg, 500 mg and 750 mg nicotinic acid tablets of the present invention have a dissolution curve similarity fit factor F.sub.2 of at least about 79, and the 1000 mg nicotinic acid tablets of the present invention have a dissolution curve similarity fit factor F.sub.2 of at least 44.
Inventor(s): Cefali; Eugenio A. (Lauderhill, FL)
Assignee: Kos Pharmaceuticals, Inc. (Miami, FL)
Application Number:08/962,424
Patent Claim Types:
see list of patent claims
Use; Formulation; Compound; Dosage form; Device;
Patent PDF download available with subscription

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International Patent Family for Patent: 6,746,691

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
World Intellectual Property Organization (WIPO)9839002Sep 11, 1998
Canada2283322Sep 11, 1998
Brazil9815457Oct 16, 2001
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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