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|Title:||Biodegradable implant precursor|
|Abstract:||The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.|
|Inventor(s):||Polson; Alan M. (Fort Collins, CO), Swanbom; Deryl D. (Fort Collins, CO), Dunn; Richard L. (Fort Collins, CO), Cox; Charles P. (Fort Collins, CO), Norton; Richard L. (Fort Collins, CO), Lowe; Bryan K. (Fort Collins, CO), Peterson; Kenneth S. (Fort Collins, CO)|
|Assignee:||Atrix Laboratories (Fort Collins, CO)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Spain||2062540||Dec 16, 1994|
|Canada||2079831||Dec 06, 2005|
|Austria||268611||Jun 15, 2004|
|Canada||2079831||Apr 29, 1993|
|Austria||100308||Feb 15, 1994|
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