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Details for Patent: 6,395,293

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Summary for Patent: 6,395,293

Title: Biodegradable implant precursor
Abstract:The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
Inventor(s): Polson; Alan M. (Fort Collins, CO), Swanbom; Deryl D. (Fort Collins, CO), Dunn; Richard L. (Fort Collins, CO), Cox; Charles P. (Fort Collins, CO), Norton; Richard L. (Fort Collins, CO), Lowe; Bryan K. (Fort Collins, CO), Peterson; Kenneth S. (Fort Collins, CO)
Assignee: Atrix Laboratories (Fort Collins, CO)
Application Number:09/520,735
Patent Claim Types:
see list of patent claims
Device; Formulation;
Patent PDF download available with subscription

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International Patent Family for Patent: 6,395,293

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Spain2062540Dec 16, 1994
Canada2079831Dec 06, 2005
Austria268611Jun 15, 2004
Canada2079831Apr 29, 1993
Austria100308Feb 15, 1994
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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