|Title:||Kits & systems for ultrasonic imaging|
|Abstract:||A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5% w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.|
|Inventor(s):||Trevino; Leo A. (San Diego, CA), Schutt; Ernest George (San Diego, CA), Klein; David H. (Carlsbad, CA), Tarara; Thomas E. (San Diego, CA), Weers; Jeffry G. (San Diego, CA), Kabalnov; Alexey (San Diego, CA)|
|Assignee:||Alliance Pharmaceutical Corp. (San Diego, CA)|
Patent Claim Types:|
see list of patent claims
|Device; Formulation; Delivery;|
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Japan||4229918||Feb 25, 2009|
|Canada||2212113||Apr 24, 2007|
|European Patent Office||0812214||Dec 17, 1997|
|Poland||321952||Jan 05, 1998|
|Canada||2212113||Sep 06, 1996|
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