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Details for Patent: 6,207,640

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Summary for Patent: 6,207,640

Title: Treatment of partial growth hormone insensitivity syndrome
Abstract:Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering an effective dose of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, a serum level of high-affinity growth hormone binding protein that is at least 2 standard deviations below normal levels, a serum level of IGF-I that is below normal mean levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I, given alone or in combination with an amount of growth hormone that is effective in combination with the IGF-I.
Inventor(s): Attie; Kenneth M. (San Francisco, CA), Carlsson; Lena M. S. (Gothenburg, SE), Gesundheit; Neil (Los Altos, CA), Goddard; Audrey (San Francisco, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:08/643,212
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International Patent Family for Patent: 6,207,640

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
Spain2160704Nov 16, 2001
Canada2252560Dec 14, 2010
JapanH09509430Sep 22, 1997
World Intellectual Property Organization (WIPO)9527495Oct 19, 1995
Mexico9701916Jun 28, 1997
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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