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Details for Patent: 6,207,640

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Patent 6,207,640 protects INCRELEX and is included in one NDA.

Summary for Patent: 6,207,640

Title: Treatment of partial growth hormone insensitivity syndrome
Abstract:Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering an effective dose of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, a serum level of high-affinity growth hormone binding protein that is at least 2 standard deviations below normal levels, a serum level of IGF-I that is below normal mean levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I, given alone or in combination with an amount of growth hormone that is effective in combination with the IGF-I.
Inventor(s): Attie; Kenneth M. (San Francisco, CA), Carlsson; Lena M. S. (Gothenburg, SE), Gesundheit; Neil (Los Altos, CA), Goddard; Audrey (San Francisco, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:08/643,212
Patent Claim Types:
see list of patent claims
Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Ipsen Inc
INCRELEX
mecasermin recombinant
INJECTABLE;SUBCUTANEOUS021839Aug 30, 2005RXYes6,207,640<disabled>TREATMENT OF PRIMARY IGF-1 DEFICIENCY
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International Patent Family for Patent: 6,207,640

Country Document Number Publication Date
World Intellectual Property Organization (WIPO)9741887Nov 13, 1997
World Intellectual Property Organization (WIPO)9527495Oct 19, 1995
United States of America5824642Oct 20, 1998
United States of America5646113Jul 08, 1997
Portugal914148Dec 31, 2003
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